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FLASH GENE
Symbol PCOLCE2 contributors: KTN/npt - updated : 30-01-2009
HGNC name procollagen C-endopeptidase enhancer 2
HGNC id 8739
Location 3q23      Physical location : 142.536.702 - 142.608.045
Synonym name procollagen COOH-terminal proteinase enhancer 2
Synonym symbol(s) PCPE2, PCPE-2
DNA
TYPE functioning gene
STRUCTURE 71.22 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D3S3711 - D3S3694 - PCOLCE2 - D3S3546 - D3S1569 - qter
Authors UCSC (2009)
Physical map
RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2 TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036 LOC391584 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RASA2 3q22-q23 RAS p21 protein activator 2 LOC389153 3 LOC389153 LOC391585 3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) RNF7 3q22-q24 ring finger protein 7 GPRK7 3q21-q24 G protein-coupled receptor kinase 7 ATP1B3 3q22-q23 ATPase, Na+/K+ transporting, beta 3 polypeptide TFDP2 3q23 transcription factor Dp-2 (E2F dimerization partner 2) MGC40579 3q23 hypothetical protein MGC40579 SEP1 3q23 strand-exchange protein 1 ATR 3q22-q24 ataxia telangiectasia and Rad3 related PLS1 3q23 plastin 1 (I isoform) TRPC1 3q22-q24 transient receptor potential cation channel, subfamily C, member 1 PCOLCE2 3q21-q24 procollagen C-endopeptidase enhancer 2 PAQR9 3q23 progestin and adipoQ receptor family member IX SR140 3q23-q24 progestin and adipoQ receptor family member IX LOC389154 3 LOC389154 CHST2 3q24 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 PBXP1 3q22-q23 pre-B-cell leukemia transcription factor pseudogene 1 SLC9A9 3p14 solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365 GM2AP 3q21-q25 GM2 ganglioside activator protein pseudogene LOC389156 3 similar to 60S ribosomal protein L21 PLOD2 3q23-q24 procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1988 45.6 415 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineneuroendocrinepituitary  highly
 pancreas    
Nervousbrain   lowly
Reproductivefemale systembreastmammary gland highly
 female systemplacenta  highly
Respiratorylung    
 respiratory tracttrachea  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text placenta highly, eye trabecular meshwork
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal signal sequence of 23 aa
  • two CUB domains at the N terminus
  • an NTR domain at the C terminus
  • a putative myristoylation site
  • several potential phosphorylation sites
  • a putative glycosylation site
  • an RGD site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Pcolce2 (87.4 pc)
    intraspecies homolog to PCOLCE
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION
  • enhancing cleavage of type I procollagen C-propeptide by BMP1 (Steiglitz 2002)
  • activating BMP1
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the COOH-terminal propeptide of type I procollagen (Steiglitz 2002)
  • interacting with heparin with high affinity and type II collagen (Steiglitz 2002)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for GLC1C (Xu 2000)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS