SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| component of the filamentous matrix of the centrosome, of the pericentriolar material |
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colocalizes with IFT proteins to the base of primary and motile cilia |
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giant coiled-coil protein localized in the pericentriolar materials as an integral component, and serves as a multifunctional scaffold by anchoring numerous proteins and protein complexes |
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in skeletal muscle, showed a perinuclear distribution |
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basic FUNCTION
| microtubule organization during cell division |
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required for assembly of the mitotic spindle apparatus |
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mediates the nucleation of microtubules by anchoring the gamma-tubulin ring complex, which initiates the assembly of the mitotic spindle apparatus |
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possible role of pericentrin in the development of cerebral vessels |
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MCPH1 and PCNT regulate mitotic entry |
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via centrosome-associated CHEK1 |
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anchors NEK2 and suppresses its kinase activity at the centrosomes, and thus, is involved in the mechanism to prevent premature centrosome splitting during interphase |
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may play a pivotal role in preventing premature centrosome splitting during interphase by inhibiting Nek2A kinase activity at the centrosome |
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may regulate the intracellular distribution and secretion of insulin |