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FLASH GENE
Symbol PCID2 contributors: mct - updated : 26-10-2016
HGNC name PCI domain containing 2
HGNC id 25653
Location 13q34      Physical location : 113.831.924 - 113.863.029
Synonym name
  • CSN12-like protein
  • Synonym symbol(s) FLJ11305, FLJ39706, FLJ99362, MGC16774, DKFZp686C20226
    DNA
    TYPE functioning gene
    STRUCTURE 44.46 kb
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 1948 - 399 - 2015 25914122
    15 - 2110 - 453 - 2015 25914122
    15 - 1980 - 399 - 2015 25914122
    15 - 1984 - 410 - 2015 25914122
    14 - 2145 - 399 - 2015 25914122
    14 - 2149 - 432 - 2015 25914122
    14 - 2283 - 397 - 2015 25914122
    14 - 2448 - 397 - 2015 25914122
    14 - 2452 - 430 - 2015 25914122
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • presence of PCID2 at the centrosome is prevalent throughout the cell cycle
  • basic FUNCTION
  • is required for the maintenance of self-renewal both in mouse and human ESCs, and plays a critical role in suppression of ESC differentiation
  • is involved in some of the same cellular processes as those of centrin 2 apart from the classical TREX-2 function
  • PCID2 but not ENY2 is also involved in protein export
  • specific novel functions for PCID2 other than mRNA export, suggesting that components of the TREX-2 complex serve alternative shared roles in the regulation of nuclear transport and cell cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCID2 is essential for B cell survival through the regulation of MAD2L1 expression during B cell differentiation
  • for the maintenance of self-renewal, PCID2 binds to EID1 to impede the association with MDM2
  • BRCA2 repair factor, which binds to SHFM1, also associates with PCID2 in the cell
  • SHFM1 binding to PCID2 with its hydrophobic core of seven AAs favorable to the binding of PCID2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS