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FLASH GENE
Symbol PCGF6 contributors: mct - updated : 07-07-2021
HGNC name polycomb group ring finger 6
HGNC id 21156
Location 10q24.33      Physical location : 105.062.553 - 105.110.891
Synonym name
  • Mel18 and Bmi1-like RING finger protein
  • ring finger protein 134
  • Synonym symbol(s) MBLR, RNF134, MGC15678, MGC17541
    DNA
    TYPE functioning gene
    STRUCTURE 48.35 kb     10 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2236 38 350 - 2016 27247273
    7 splicing 2011 30 275 - 2016 27247273
  • 7 exons
  • lacking an in-frame segment of the coding region compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Skin/Tegumentskin   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion moderately in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal proline-rich region
  • a glutamine-rich region
  • a central domain including a RING finger motif
  • HOMOLOGY
    interspecies homolog to rattus Pcgf6 (91.6 pc)
    homolog to murione Pcgf6 (91.7 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • localized in a fine-grained distribution throughout the nucleoplasm in interphase cells and in a fainter diffuse cytoplasmic distribution in mitotic cells
  • basic FUNCTION
  • functioning as transcription repressor
  • may modulate the levels of histone H3K4Me3 by activating JARID1D histone demethylase
  • is required to maintain embryonic stem cell (ESC) identity
  • negatively regulates dendritic cell activation and promotes quiescence
  • involved in the regulation of progression through cell cycle
  • PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions
  • has a critical role in safeguarding lineage decisions and in preventing aberrant expression of germ cell-related genes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with BMI1/PCGF4, RING1 and RNF2
  • interacting with JARID1D
  • novel roles for PCGF6 in directly regulating POU5F1, NANOG, SOX2, and LIN28A expression to maintain ESC identity
  • cell & other
    REGULATION
    Other regulated by cell cycle dependent phosphorylation (phosphorylated during mitosis)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS