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FLASH GENE
Symbol PCF11 contributors: mct - updated : 04-04-2008
HGNC name PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
HGNC id 30097
Location 11q13      Physical location : 82.868.136 - 82.896.833
Synonym name
  • pre-mRNA cleavage complex II protein Pcf11
  • Synonym symbol(s) KIAA0824
    DNA
    TYPE functioning gene
    STRUCTURE 28.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390227 11 similar to origin recognition complex, subunit 3 isoform 2; homolog of latheo, Drosophila MGC33846 11q13.5 hypothetical protein MGC33846 LOC143543 11q13.5 similar to Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA binding motif protein, X chromosome) (Glycoprotein p43) PRCP 11q14 prolylcarboxypeptidase (angiotensinase C) FLJ25416 11q13.5 hypothetical protein FLJ25416 LOC390228 11 hypothetical gene supported by AK058145 RAB30 11q12-q14 RAB30, member RAS oncogene family PCF11 11q13 pre-mRNA cleavage complex II protein Pcf11 DKFZp547G183 11q13.5 hypothetical protein DKFZp547G183 FLJ37874 11q13.5-q14.1 hypothetical protein FLJ37874 MDS025 11q14.1 hypothetical protein MDS025 HCP28 11q14.1 cytochrome c, somatic pseudogene FLJ37266 11q14.1 hypothetical protein FLJ37266 DLG2 11q21 discs, large homolog 2, chapsyn-110 (Drosophila) LOC390229 11 similar to HNRPC protein LOC143548 11q14.1 similar to REST corepressor HT007 11q14.1 uncharacterized hypothalamus protein HT007 DKFZp586C1924 11q14.1 hypothetical protein DKFZp586C1924 ZF 11q14 HCF-binding transcription factor Zhangfei FLJ38159 11q14.1 hypothetical protein FLJ38159 SYTL2 11q14 synaptotagmin-like 2 MGC34732 11q14.1 hypothetical protein MGC34732 PICALM 11q14 phosphatidylinositol binding clathrin assembly protein LOC283226 11q14.1 similar to Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (CAAX farnesyltransferase alpha subunit) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase alpha sub EED 11q14.2-q22.3 embryonic ectoderm development HSPC138 11q14.1 hypothetical protein HSPC138
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5932 - 1555 - West (2008)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for the efficient degradation of the 3' product of polyA site cleavage
  • enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • mRNA cleavage
  • a component
  • pre-mRNA cleavage factor complex
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS