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FLASH GENE
Symbol PCF11 contributors: mct - updated : 04-04-2008
HGNC name PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
HGNC id 30097
Location 11q13      Physical location : 82.868.136 - 82.896.833
Synonym name
  • pre-mRNA cleavage complex II protein Pcf11
  • Synonym symbol(s) KIAA0824
    DNA
    TYPE functioning gene
    STRUCTURE 28.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5932 - 1555 - West (2008)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for the efficient degradation of the 3' product of polyA site cleavage
  • enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • mRNA cleavage
  • a component
  • pre-mRNA cleavage factor complex
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS