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FLASH GENE
Symbol PCDHGA8 contributors: - updated : 17-05-2006
HGNC name protocadherin gamma subfamily A, 8
HGNC id 8706
Location 5q31.3      Physical location : 140.771.482 - 140.892.546
Synonym name
  • protocadherin,cadherin related neuronal receptor,gamma A8,in the gamma cluster
  • cDNA sequence,expressed in brain,93kDa,related to protocadherin 43
  • Synonym symbol(s) PCDHVGA8,PCDH-GAMMA-A8,KIAA0327
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    text component of PCDHG@,subfamily A
    STRUCTURE 121.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure the first large exon corresponding to the variable region A8 of the gamma cluster encodes the N terminal extracellular transmembrane domains, the three small last exons corresponding the constant region of the gamma cluster encode the C terminal cytoplasmic domain (identical for each protein in the cluster)
    MAPPING cloned Y linked Y status provisional
    Map cen - PCDHGA1 - PCDHGA2 - PCDHGA3 - PCDHGB1 - PCDHGA4 - PCDHGB2 - PCDHGA5 - PCDHGB3 - PCDHGA6 - PCDHGA7 - PCDHGB4 - PCDHGA8 - PCDHGB5 - PCDHGA9 - PCDHGB6 - PCDHGA10 - PCDHGB7 - PCDHGA11 - PCDHGA12 - PCDHGC3 - PCDHGC4 - PCDHGC5 - qter
    Authors Wu (01)
    Physical map
    PCDHB10 5q31.3 protocadherin beta 10 PCDHB11 5q31.3 protocadherin beta 11 PCDHB12 5q31.3 protocadherin beta 12 PCDHB13 5q31.3 protocadherin beta 13 PCDHB14 5q31.3 protocadherin beta 14 PCDHB18 5q31.3 protocadherin beta 18 pseudogene PCDHB19P 5q31 protocadherin beta 19 pseudogene PCDHB15 5q31.3 protocadherin beta 15 SLC25A2 5q31 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member TAF7 5q31 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa PCDHGA1 5q31.3 protocadherin gamma subfamily A, 1 PCDHGA2 5q31.3 protocadherin gamma subfamily A, 2 PCDHGA3 5q31.3 protocadherin gamma subfamily A, 3 PCDHGB1 5q31.3 protocadherin gamma subfamily B, 1 PCDHGA4 5q31.3 protocadherin gamma subfamily A, 4 PCDHGB2 5q31.3 protocadherin gamma subfamily B, 2 PCDHGA5 5q31.3 protocadherin gamma subfamily A, 5 PCDHGB3 5q31.3 protocadherin gamma subfamily B, 3 PCDHGA6 5q31.3 protocadherin gamma subfamily A, 6 PCDHGA7 5q31.3 protocadherin gamma subfamily A, 7 PCDHGB4 5q31.3 protocadherin gamma subfamily B, 4 PCDHGA8 5q31.3 protocadherin gamma subfamily A, 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5500 101.7 932 - Nagase
    variable region A8 and constant region of gamma cluster
    - - 3500 90 820 brain Nagase
    terminating downstream intron 1,putatively secreted
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a signal peptide,six extracellular cadherin repeats,a transmembrane segment encoded by a unique exonand a cytoplasmic tail identical for each protein in the cluster
    conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pcdhga8 protocadherin gamma subfamily A,8
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type I, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
  • playing a putative role in cell-cell interactions critical in the development of the central nervous system
  • mediating adhesion in synaptic junctions through lack-in process
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein cytoplasmic domain putatively connecting to intermediate filaments
    cell & other cells expressing the same protocadherin
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS