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FLASH GENE
Symbol PCDHGA12 contributors: - updated : 27-09-2004
HGNC name protocadherin gamma subfamily A, 12
HGNC id 8699
Location 5q31.3      Physical location : 140.810.157 - 140.892.546
Synonym name
  • cadherin 21,fibroblast cadherin FIB3
  • protocadherin,cadherin related neuronal receptor,gamma A12,in the gamma cluster
    • Synonym symbol(s) KIAA0588, FIB3, PCDHVGA12, CDH21
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    text component of PCDHG@,subfamily A
    STRUCTURE 82.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure the first large exon corresponding to the variable region A12 of the gamma cluster encodes the N terminal extracellular transmembrane domains, the three small last exons corresponding the constant region of the gamma cluster encode the C terminal cytoplasmic domain (identical for each protein in the cluster)
    MAPPING cloned Y linked Y status provisional
    Map cen - PCDHGA1 - PCDHGA2 - PCDHGA3 - PCDHGB1 - PCDHGA4 - PCDHGB2 - PCDHGA5 - PCDHGB3 - PCDHGA6 - PCDHGA7 - PCDHGB4 - PCDHGA8 - PCDHGB5 - PCDHGA9 - PCDHGB6 - PCDHGA10 - PCDHGB7 - PCDHGA11 - PCDHGA12 - PCDHGC3 - PCDHGC4 - PCDHGC5 - qter
    Authors Wu (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4800 101 932 - Matsuyoshi
    variable region A12 and constant region of gamma cluster
    - - 2600 - 820 - Matsuyoshi
    variable region A12 of gamma cluster, putatively secreted
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		six extracellular cadherin repeats,a transmembrane segment and a cytoplasmic tail identical for each protein in the cluster
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pcdhga12 protocadherin gamma subfamily A,12
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type I, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text playing a putative role in cell-cell interactions critical in the development of the central nervous system,mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein cytoplasmic domain putatively connecting to intermediate filaments
    cell & other cells expressing in the same protocadherin
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS