Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PCDHGA10 contributors: - updated : 03-05-2004
HGNC name protocadherin gamma subfamily A, 10
HGNC id 8697
Location 5q31.3      Physical location : 140.792.742 - 140.892.546
Genatlas name protocadherin,cadherin related neuronal receptor,gamma A10,in the gamma cluster
Synonym symbol(s) PCDHVGA10,PCDH-GAMMA-A9
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text component of PCDHG@,subfamily A
STRUCTURE 99.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure the first large exon corresponding to the variable region A10 of the gamma cluster encodes the N terminal extracellular transmembrane domains, the three small last exons corresponding the constant region of the gamma cluster encode the C terminal cytoplasmic domain (identical for each protein in the cluster)
MAPPING cloned Y linked Y status provisional
Map cen - PCDHGA1 - PCDHGA2 - PCDHGA3 - PCDHGB1 - PCDHGA4 - PCDHGB2 - PCDHGA5 - PCDHGB3 - PCDHGA6 - PCDHGA7 - PCDHGB4 - PCDHGA8 - PCDHGB5 - PCDHGA9 - PCDHGB6 - PCDHGA10 - PCDHGB7 - PCDHGA11 - PCDHGA12 - PCDHGC3 - PCDHGC4 - PCDHGC5 - qter
Authors Wu (01)
Physical map
SLC25A2 5q31 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member TAF7 5q31 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa PCDHGA1 5q31.3 protocadherin gamma subfamily A, 1 PCDHGA2 5q31.3 protocadherin gamma subfamily A, 2 PCDHGA3 5q31.3 protocadherin gamma subfamily A, 3 PCDHGB1 5q31.3 protocadherin gamma subfamily B, 1 PCDHGA4 5q31.3 protocadherin gamma subfamily A, 4 PCDHGB2 5q31.3 protocadherin gamma subfamily B, 2 PCDHGA5 5q31.3 protocadherin gamma subfamily A, 5 PCDHGB3 5q31.3 protocadherin gamma subfamily B, 3 PCDHGA6 5q31.3 protocadherin gamma subfamily A, 6 PCDHGA7 5q31.3 protocadherin gamma subfamily A, 7 PCDHGB4 5q31.3 protocadherin gamma subfamily B, 4 PCDHGA8 5q31.3 protocadherin gamma subfamily A, 8 PCDHGB5 5q31.3 protocadherin gamma subfamily B, 5 PCDHGA9 5q31.3 protocadherin gamma subfamily A, 9 PCDHGB6 5q31.3 protocadherin gamma subfamily B, 6 PCDHGA10 5q31.3 protocadherin gamma subfamily A, 10 PCDHGB7 5q31.3 protocadherin gamma subfamily B, 7 PCDHGA11 5q31.3 protocadherin gamma subfamily A, 11 PCDHGB8P 5q31.3 protocadherin gamma subfamily B, 8 pseudogene PCDHGA12 5q31.3 protocadherin gamma subfamily A, 12 PCDHGC3 5q31.3 protocadherin gamma subfamily C, 3 PCDHGC4 5q31.3 protocadherin gamma subfamily C, 4 PCDHGC5 5q31.3 protocadherin gamma subfamily C, 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4600 101.4 936 - Wu
variable region A10 and constant region of gamma cluster
- - 2600 - 850 - Wu
terminating downstream intron 1,putatively secreted
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a signal peptide,six extracellular cadherin repeats,a transmembrane segment encoded by a unique exon and a cytoplasmic tail identical for each protein in the cluster
conjugated GlycoP
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Pcdhga10 protocadherin gamma subfamily A,10
intraspecies homolog to cadherin
Homologene
FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type I, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text playing a putative role in cell-cell interactions critical in the development of the central nervous system,mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein cytoplasmic domain putatively connecting to intermediate filaments
    cell & other cells expressing the same protocadherin
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS