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FLASH GENE
Symbol PCDHB16 contributors: npt - updated : 14/10/2008
HGNC name protocadherin beta 16
HGNC id 14546
Location 5q31.3      Physical location : 140.560.979 - 140.565.795
Synonym name
  • cadherin ME1
  • protocadherin beta 8a
  • protocadherin 3X
  • protocadherin, cadherin related neuronal receptor, beta 16 in the beta cluster
  • Synonym symbol(s) PCDH-BETA16, ME1, PCDH3X, PCDHB8A, KIAA1621
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    text component of PCDHB@
    STRUCTURE 4.82 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure one large coding exon
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4827 81.8 776 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines melanoma, fibroblast cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • six extracellular cadherin repeats
  • a transmembrane segment
  • a cytoplasmic tail
  • one PXXP motif
  • a putative SH3 protein-binding site, lacking a constant region
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pcdhb16 protocadherin beta 16
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type I, localized at the synaptic junction
    basic FUNCTION
  • cadherin related neuronal receptor, putatively involved in the specificity of the neuronal connections
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • playing a putative role in cell-cell interactions critical in the develoment of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
  • PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • cytoplasmic domain putatively connecting to intermediate filament
  • cell & other
  • cells expressing in the same protocadherin
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS