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FLASH GENE
Symbol PCDHB13 contributors: npt - updated : 09/10/2008
HGNC name protocadherin beta 13
HGNC id 8684
Location 5q31.3      Physical location : 140.593.508 - 140.596.993
Synonym name
  • protocadherin, cadherin related neuronal receptor, beta 13 in the beta cluster
  • Synonym symbol(s) PCDHVB13, PCDH-BETA13
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    text component of PCDHB@
    STRUCTURE 3.48 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure one large coding exon
    MAPPING cloned Y linked N status confirmed
    Physical map
    PCDHB1 5q31.3 protocadherin beta 1 PCDHB2 5q31.3 protocadherin beta 2 PCDHB3 5q31.3 protocadherin beta 3 PCDHB4 5q31.3 protocadherin beta 4 PCDHB5 5q31.3 protocadherin beta 5 PCDHB6 5q31.3 protocadherin beta 6 PCDHB17 5q31.3 protocadherin beta 17 pseudogene PCDHB7 5q31.3 protocadherin beta 7 PCDHB8 5q31.3 protocadherin beta 8 PCDHB16 5q31.3 protocadherin beta 16 PCDHB9 5q31.3 protocadherin beta 9 PCDHB10 5q31.3 protocadherin beta 10 PCDHB11 5q31.3 protocadherin beta 11 PCDHB12 5q31.3 protocadherin beta 12 PCDHB13 5q31.3 protocadherin beta 13 PCDHB14 5q31.3 protocadherin beta 14 PCDHB18 5q31.3 protocadherin beta 18 pseudogene PCDHB19P 5q31 protocadherin beta 19 pseudogene PCDHB15 5q31.3 protocadherin beta 15 SLC25A2 5q31 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member TAF7 5q31 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa PCDHGA1 5q31.3 protocadherin gamma subfamily A, 1 PCDHGA2 5q31.3 protocadherin gamma subfamily A, 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3485 84.5 798 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • six extracellular cadherin repeats
  • a transmembrane segment
  • a cytoplasmic tail
  • one PXXP motif
  • a putative SH3 protein-binding site, lacking a constant region
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pcdhb13 protocadherin beta 13
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type 1, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text playing a putative role in cell-cell interactions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • cytoplasmic domain putatively connecting to intermediate filaments
  • cell & other
  • cells expressing in the same protocadherin
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS