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FLASH GENE
Symbol PCDHA11 contributors: - updated : 04-05-2004
HGNC name protocadherin alpha 11
HGNC id 8665
Location 5q31.3      Physical location : 140.247.830 - 140.391.929
Genatlas name protocadherin,cadherin related neuronal receptor,alpha 11 in the alpha cluster
Synonym name ortholog to mouse Cnr7
Synonym symbol(s) PCDHVA11,PCDHALPHA11,CNR7,CNRN7,KIAA0345-like3
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text component of PCDHA@
STRUCTURE 144.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   other
text structure
  • the first large exon corresponding to the variable region A11 of the alpha cluster encodes the N terminal extacellular and transmembrane domains
  • the three small last exons corresponding to the constantregion of the alpha cluster encode the C terminal cytoplasmic domain (identical for each protein in the cluster)
  • MAPPING cloned Y linked   status confirmed
    Physical map
    NDUFA2 5q31.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa IK 2p15-p14 IK cytokine, down-regulator of HLA II FLJ20195 5q31.3 hypothetical protein FLJ20195 DND1 5q31.3 dead end homolog 1 (zebrafish) HARS 5q31.1 histidyl-tRNA synthetase HARSL 5q31.1-q33.2 histidyl-tRNA synthetase-like FLJ31121 5q31.3 hypothetical protein FLJ31121 PCDHA1 5q31.3 protocadherin alpha 1 PCDHA2 5q31.3 protocadherin alpha 2 PCDHA3 5q31.3 protocadherin alpha 3 PCDHA4 5q31.3 protocadherin alpha 4 PCDHA5 5q31.3 protocadherin alpha 5 PCDHA6 5q31.3 protocadherin alpha 6 PCDHA7 5q31.3 protocadherin alpha 7 PCDHA8 5q31.3 protocadherin alpha 8 PCDHA9 5q31.3 protocadherin alpha 9 PCDHA10 5q31.3 protocadherin alpha 10 PCDHA14 5q31.3 protocadherin gamma subfamily A 14 pseudogene PCDHA11 5q31.3 protocadherin alpha 11 PCDHA12 5q31.3 protocadherin alpha 12 PCDHA13 5q31.3 protocadherin alpha 13 PCDHAC1 5q31.3 protocadherin alpha subfamily C, 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 6100 103 949 - Wu
    variable region A11,constant region of the alpha cluster
    - - 3300 87 810 - Wu
    terminating downstream intron 1,putatively secreted
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a signal peptide,six extracellular cadherin repeats,a transmembrane segment encoded by a unique exon encoded by a unique exon,and a cytoplasmic tail identical for each protein in the cluster,containing two PXXP motifs and a putative SH3 protein-binding site
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pcdha11 protocadherin alpha 11
    homolog to rattus norvegicus Pcdha11 protocadherin alpha 11
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin family
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type 1,localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text playing a putative role in cell-cell interaction critical in the development of the central nervous system,mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein cytoplasmic domain putatively connecting to intermediate filaments
    cell & other cells expressing in the same protocadherin
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS