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FLASH GENE
Symbol PCDH9 contributors: mct - updated : 21-04-2020
HGNC name protocadherin 9
HGNC id 8661
Location 13q21.32      Physical location : 66.876.966 - 67.804.468
Synonym name cadherin superfamily protein VR4-11
DNA
TYPE functioning gene
STRUCTURE 927.50 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D13S300 - D13S137 - PCDH8 - D13S155 - D13S59 - PCDH9 - D13S288 - qter
Authors Strehl (98)
RNA
TRANSCRIPTS type messenger
text two or more mRNAs of different sizes expressed in a variety of tissues
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 6227 - 1237 - 2017 28791409
5 - 6101 - 1195 - 2017 28791409
4 - 6125 - 1203 - 2017 28791409
4 - 5999 - 1161 - 2017 28791409
2 - 28118 - 1032 - 2017 28791409
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
 brainforebraincerebral lobefrontal 
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
Text other tissues with a developmentally regulated expression pattern
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide,six extracellular cadherin repeats and a transmembrane domain encoded by a large unique exon and a distinct cytoplasmic tail specifically interacting with tyrosine kinases
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pcdh9 protocadherin 9
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral plasma membrane localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
  • may play specific roles in the establishment of selective synaptic connections of specific modality of cerebral cortex with other communicating brain regions such as the thalamus
  • play likely roles in the wiring of neural circuit formation and maintenance through its adhesive and regulatory mechanism
  • PCDH8, PCDH9, PCDH17 and PCDH20 genes are located around 13q21.1 and might be broadly involved in tumor suppression in a variety of tumors
  • might be involved in formation of specific neural circuits during neural development
  • PCDH9 is likely a novel risk gene for major depressive disorder (MDD)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • playing a putative role in cell-cell interactions critical in the development of the central nervous system,mediating adhesion in synaptic junctions through lack-in process
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • PCDH9 is a novel regulator of EMT by increasing the activity of GSK3B and inhibiting SNAI1
  • cell & other cells expressing in the same protocadherin
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by methylation of the PCDH9 promoter observed in 22p100 primary hepatocellular carcinoma (HCC), associated with a larger tumor size and a more pronounced intrahepatic dissemination
    tumoral     --low  
    during the development and progression of gastric cancer
    Susceptibility to major depressive disorder (MDD)
    Variant & Polymorphism SNP
  • rs9540720 in the PCDH9 gene was genome-wide significantly associated with MDD
  • Candidate gene
    Marker
  • PCDH9 could be a promising biomarker of the gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    restored PCDH9 expression could inhibit cell proliferation of HCC cell lines via inducing cell cycle arrest at G0/G1 phase
    ANIMAL & CELL MODELS