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FLASH GENE
Symbol PCDH8 contributors: mct - updated : 02-11-2011
HGNC name protocadherin 8
HGNC id 8660
Location 13q14.3      Physical location : 53.418.110 - 53.422.774
Synonym name
  • arcadlin
  • Paraxial protocadherin
  • Synonym symbol(s) PAPC, ARCADLIN
    DNA
    TYPE functioning gene
    STRUCTURE 4.67 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D13S300 - D13S137 - PCDH8 - D13S155 - D13S59 - PCDH9 - D13S288 - qter
    Physical map
    WDFY2 13q14.12 WD repeat and FYVE domain containing 2 FLJ13639 13q14.2 hypothetical protein FLJ13639 FLJ37307 13q14.2 hypothetical protein FLJ37307 DKFZP434K1172 13q14.2 hypothetical protein DKFZp434K1172 LOC387926 13 hypothetical gene supported by AF338231; BC030655 ATP7B 13q14.3 ATPase, Cu++ transporting, beta polypeptide (Wilson disease) KIAA0266 13q12.2-q13.3 KIAA0266 protein LOC387927 13 similar to BB049667 protein MGC75495 13q14.2 similar to Serine/threonine-protein kinase Nek1 (NimA-related protein kinase 1) NEK3 13q14.2-q21.1 NIMA (never in mitosis gene a)-related kinase 3 LOC387928 13 similar to mitochondrial ribosomal protein S31; imogen 38 TPTEps1 13q14.2 TPTE and PTEN homologous inositol lipid phosphatase pseudogene THSD1 13q14.13 thrombospondin, type I, domain 1 C13orf9 13q14.13 chromosome 13 open reading frame 9 CKAP2 13q14 cytoskeleton associated protein 2 LOC387929 13 LOC387929 LOC220115 13q14.2 TPTE pseudogene LOC144983 13q14.2 hypothetical protein LOC144983 SUGT1 13q14.2 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) LECT1 13q14-q21 leukocyte cell derived chemotaxin 1 LOC121981 13q14.2 similar to peptidyl-Pro cis trans isomerase PCDH8 13q14.3 protocadherin 8 GW112 13q14.2 differentially expressed in hematopoietic lineages
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 4076 113 1070 - 1998 9787079
    3 - 3785 100 973 - 1998 9787079
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • six extracellular cadherin repeats
  • a transmembrane domain encoded by a large unique exon and a distinct cytoplasmic tail specifically interacting with tyrosine kinases, with two conserved motifs
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pcdh8 protocadherin 8
    homolog to rattus norvegicus Pcdh8 protocadherin 8
    homolog to zebrafish Danio rerio pcdh8 protocadherin 8
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral plasma membrane localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
  • loss of PCDH8 promotes oncogenesis in epithelial human cancers by disrupting cell-cell communication dedicated to tissue organization and repression of mitogenic signaling
  • functions as a molecular "governor" to maintain FLRT3 activity at the optimal level for physiological regulation of C-cadherin adhesion, cell sorting, and morphogenesis)
  • PCDH8 signaling via RHOA and WNT5a/ROR2 activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text putative role in cell-cellinteractions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
  • PCDH8 and FLRT3 form a functional complex with cadherins
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • WNT-11/FZD7 controls cell adhesion by forming separate adhesion-modulating complexes (AMCs) with the paraxial protocadherin PCDH8 and C-cadherin via distinct FZD7 interaction domains
  • cell & other
  • cells expressing in the same protocadherin
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by promoter region methylation in primary renal cell carcinoma
    tumoral       loss of function
    through either mutation or epigenetic silencing in a high fraction of breast carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS