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FLASH GENE

Symbol

PCDH11Y

contributors: - updated : 31-01-2006

HGNC name	protocadherin 11 Y-linked
HGNC id	15813

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Yp11.2      Physical location : 4.868.266 - 5.610.258
Synonym symbol(s)	PCDHY, PCDH22

DNA

TYPE	functioning gene
STRUCTURE	686.00 kb     5 Exon(s)    single Copie(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PCDH-Va - - 4700 117 1037 - Blanco PCDH-Vb - - 5000 120 1048 - Blanco PCDH-Vc - - 9100 145 1340 - Blanco

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain diencephalon amygdala       brain forebrain cerebral cortex     Reproductive male system testis       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular         Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide sequence (larger than in PCDHX)
	seven extracellular cadherin repeats
	twenty four aminoacid transmembrane strech, joining a unique cytoplasmic tail (shorter than in PCDHX)

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to cadherin

Homologene

FAMILY	cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
	protocadherin gene family

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,nuclear envelope,int

basic FUNCTION	playing a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
	cadherin related neuronal receptor, putatively involved in the specificity of the neuronal connections

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

PATHWAY

metabolism

signaling

signal transduction

cell-cell signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein

cell & other

cell cell homophiic interaction

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS