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FLASH GENE

Symbol

PCDH1

contributors: - updated : 31-01-2006

HGNC name	protocadherin 1 (cadherin-like 1)
HGNC id	8655

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q32-33      Physical location : 141.232.682 - 141.257.944
Synonym name	protocadherin 42
Synonym symbol(s)	HGNC8655, MGC45991, PC42, PCDH42

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	component of the PCDHG cluster,member C3
STRUCTURE	15.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 4340 110 1026 - Sano variant 2 - - 5000 130 1203 nervous system Sano divergent in the N terminus

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cells

System Cell Pubmed Species Stage Rna symbol Nervous glia

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	seven extracellular cadherin repeats
	a transmembrane segment encoded by a large unique exon and a C terminal cytoplasmic tail

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

intraspecies

homolog to cadherin

Homologene

FAMILY	cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
	protocadherin subfamily

CATEGORY

adhesion , signaling , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,nuclear envelope,int
text	integral plasma membrane,localized at the synaptic junction

basic FUNCTION

cadherin-related neuronal receptor, putatively involved in specific neuronal connections, mediating adhesion in synaptic junctions through lack-in process

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

cell-cell signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein

cell & other

cell cell homophilic interaction

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS