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FLASH GENE
Symbol PCBP3 contributors: mct - updated : 26-01-2013
HGNC name poly(rC) binding protein 3
HGNC id 8651
Location 21q22.3      Physical location : 47.269.874 - 47.362.367
Synonym name rCbinding protein 3
Synonym symbol(s) ACP3, ALPHA-CP3
DNA
TYPE functioning gene
STRUCTURE 92.49 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ITGB2 21q22.3 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) C21orf69 21q22.3 chromosome 21 open reading frame 69 C21orf67 21q22.3 chromosome 21 open reading frame 67 C21orf70 21q22.3 chromosome 21 open reading frame 70 LOC391283 21 similar to interspersed repeat antigen, putative C21orf122 21q22.3 chromosome 21 open reading frame 122 ADARB1 21q22.3 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) C21orf89 21q22.1 chromosome 21 open reading frame 89 C21orf80 21q22.3 chromosome 21 open reading frame 80 C21orf86 21q22.1 chromosome 21 open reading frame 86 C21orf93 21q22.1 chromosome 21 open reading frame 93 LOC388830 21 similar to PRED59 COL18A1 21q22.3 collagen, type XVIII, alpha 1 LOC388831 21 LOC388831 SLC19A1 21q22.3 solute carrier family 19 (folate transporter), member 1 LOC388832 21 hypothetical gene supported by BC020585 LOC388833 21 LOC388833 PCBP3 21q22.3 poly(rC) binding protein 3 COL6A1 21q22.3 collagen, type VI, alpha 1 LOC200292 21q22.3 hypothetical LOC200292 COL6A2 21q22.3 collagen, type VI, alpha 2 FTCD 21q22.3 formiminotransferase cyclodeaminase C21orf56 21q22.3 chromosome 21 open reading frame 56 LSS 21q22.3 lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) MCM3APAS 21q22.3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein, antisense C21orf85 21q22.1 chromosome 21 open reading frame 85 MCM3AP 21q22.3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein C21orf57 21q22.3 chromosome 21 open reading frame 57 C21orf58 21q22.3 chromosome 21 open reading frame 58 PCNT2 21q22.3 pericentrin 2 (kendrin) LOC388834 21 hypothetical gene supported by AK127572 C21orf106 21q22.3 chromosome 21 open reading frame 106 S100B 21q22.3 S100 calcium binding protein, beta (neural) HRMT1L1 21q22.3 HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae) RPL23AP4 21q22.3 ribosomal protein L23a pseudogene 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2000 - 371 - 2012 22521865
13 - 1922 - 342 - 2012 22521865
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
RNA binding protein with three k homology (KH) motifs, playing an important role in the regulation of translation of eukaryotic mRNA
HOMOLOGY
Homologene
FAMILY
  • PCBP family, KH-domain protein subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • post-transcriptional control
  • can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level
  • modestly activates splicing of MAPT exon 10 by interacting with its proximal downstream intron , suggesting a pathogenic role of PCBP3 and other splicing factors on chromosome 21 in neurodegenerative diseases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS