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FLASH GENE
Symbol PCBP1 contributors: mct/npt/pgu - updated : 03-01-2013
HGNC name poly(rC) binding protein 1
HGNC id 8647
Location 2p13.3      Physical location : 70.314.584 - 70.316.332
Synonym name
  • nucleic acid binding protein sub 2.3
  • heterogenous nuclear ribonucleoprotein X
  • heterogenous nuclear ribonucleoprotein E1
    • Synonym symbol(s) ACP1, HNRPE1, HNRPX, , hnRNP-E1, hnRNP-X
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text generated by retrotransposition of a fully processed PCBP-2 mRNA
    STRUCTURE 1.75 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GKN1 2p13.3 gastrokine 1 ANTXR1 2p13.1 anthrax toxin receptor 1 GFPT1 2p13 glutamine-fructose-6-phosphate transaminase 1 HIRIP5 2p12 HIRA interacting protein 5 LOC388957 2 similar to expressed sequence C79663 LOC388958 2 hypothetical gene supported by AF090101 AAK1 2p24.3-p14 AP2 associated kinase 1 ANXA4 2p13 annexin A4 FLJ13057 2p13.3 hypothetical protein FLJ13057 similar to germ cell-less RY1 2p13.3 putative nucleic acid binding protein RY-1 MAD 2p12 MAX dimerization protein 1 FLJ25084 2p13.3 hypothetical protein FLJ25084 PCBP1 2p13-p12 poly(rC) binding protein 1 LOC151518 2p13.3 hypothetical LOC151518 MRPL36P1 2p13.2 hypothetical LOC151518 FLJ20558 2p13.3 hypothetical protein FLJ20558 TIA1 2p13 TIA1 cytotoxic granule-associated RNA binding protein PCYOX1 2p13.3 prenylcysteine oxidase 1 SNRPG 2p12 small nuclear ribonucleoprotein polypeptide G FLJ14668 2p13.3 hypothetical protein FLJ14668 TGFA 2p13 transforming growth factor, alpha ADD2 2p14-p13 adducin 2 (beta) CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 CD207 2p13 CD207 antigen, langerin VAX2 2p13.3 ventral anterior homeobox 2 ATP6V1B1 2p13 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1 (Renal tubular acidosis with deafness) FLJ12056 2p13.2 hypothetical protein FLJ12056 TEX261 2p13.2 testis expressed gene 261 LOC115131 2p13.2 similar to POSSIBLE GUSTATORY RECEPTOR CLONE PTE01 OR7E91P 2p12 olfactory receptor, family 7, subfamily E, member 91 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1772 37.5 356 - 2007 17622584
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinesmall intestine  lowly
     liver   lowly
    Endocrinepancreas   highly
     thyroid   lowly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemovary  lowly
     male systemtestis  lowly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three K homology (KH) motifs, playing an important role in the regulation of translation of eukaryotic mRNA
    • conjugated RiboP , PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Pcbp1
    homolog to drosophila mub
    homolog to C.elegans Y119D3B.17 and F26B1.2
    intraspecies paralog to PCBP2
    paralog to PCBP3
    paralog to PCBP4
    Homologene
    FAMILY hnRNP family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • loosely bound in the nucleus
  • shuttle between the nucleus and the cytoplasm
    • basic FUNCTION
  • functioning as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES
  • regulating the translation of reticulocyte 15-lipoxygenase (ALOX15) mRNA
  • promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure
  • implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA
  • playing a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability
  • can function as a cytosolic iron chaperone in the delivery of iron to ferritin
  • functions as a RNA-binding, as well as DNA-binding, protein
  • bifunctional protein acting as both an iron-binding and an RNA binding protein
  • PCBP1 plays a major role in the dynamic expression of AR in both male and female androgen-responsive cells
  • physiologically relevant, sensitive, cellular sensor of folate deficiency
  • iron chaperone that binds iron and delivers it to ferritin, a cytosolic iron storage protein
  • required for iron incorporation into prolyl hydroxylase
  • broad role for PCBP1 and PCBP2 in delivering iron to cytosolic nonheme iron enzymes
  • critical role of PCBP1 in regulating mitochondrial antiviral signaling for both fine-tuning the antiviral immunity and preventing inflammation
  • may be important in the pathogenesis of gestational trophoblastic tumors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    mRNA metabolism
    a component
    INTERACTION
    DNA binding to single-stranded DNA
    RNA binding to poliovirus RNA by its 5'-terminal cloverleaf structure
    small molecule
    protein
  • interacting with REN, ELAVL1, and HADHB
  • alternative splicing functions of PCBP1 mediated by its intrinsic interaction with RBM39, a U2 snRNP auxiliary factor-related protein previously implicated in RNA splicing
  • with PCBP2, bind specifically to sequences within multiple cellular or viral mRNA species with a consequent increase in the stability of the messages or alteration of their translation efficiency
  • inverse correlation between protein levels of PTP4A3 and PCBP1 in human primary cancers
  • THAP11 is a novel physiological binding partner of PCBP1
  • expressional regulator of the mu-opioid receptor (OPRM1) gene
  • novel role of GNB2L1, physically interacting with PCBP1 and participating in the regulation of OPRM1 gene expression in neuronal NMB cells
    • cell & other
    REGULATION
    Other non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    decreased expression of PCBP1 protein may be a strong predictor of the malignant transformation of complete moles
    constitutional     --over  
    impairs mitochondrial antiviral signaling -mediated antiviral responses
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS