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FLASH GENE
Symbol PCBD2 contributors: - updated : 18-12-2006
HGNC name pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
HGNC id 24474
Location 5q31.2      Physical location : 134.240.809 - 134.298.335
Synonym name
  • HNF1-alpha dimerization cofactor
  • dimerization cofactor of hepatocyte nuclear factor 1 ( HNF1) from muscle
  • 6-pyruvoyl-tetrahydropterin synthase
  • dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
  • DcoH-like protein DCoHm
    • Synonym symbol(s) DKFZp566K1946, DCOHM, DCOH2
    EC.number 4.2.1.96
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text in head-to-tail orientation with CATSPER3
    STRUCTURE 64.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer
    HOMOLOGY
    interspecies ortholog to C.elegans 1H529
    intraspecies homolog to PCBD
    Homologene
    FAMILY
  • DCOH family
  • pterin-4-alpha-carbinolamine dehydratase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION stabilizing HNF1-alpha as a dimer
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming a 2:2 complex with HNF1 in vitro
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forms a complex with HNF1-alpha and Mirk (Mirk/Dyrk1B is an arginine-directed serine/threonine protein kinase)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS