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FLASH GENE
Symbol PBXIP1 contributors: mct - updated : 03-01-2023
HGNC name pre-B-cell leukemia transcription factor interacting protein 1
HGNC id 21199
Location 1q21.3      Physical location : 154.916.560 - 154.928.567
Synonym name hematopoietic PBX-interacting protein
Synonym symbol(s) HPIP
DNA
TYPE functioning gene
STRUCTURE 12.02 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • erythroid lineage-specific transcription factor GATA1 binds to the HPIP promoter and activates HPIP gene transcription in a CCCTC-binding factor (CTCF)-dependent manner
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2787 - 576 - 2012 22187427
    10 - 3118 - 702 - 2012 22187427
    11 - 3207 - 731 - 2012 22187427
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome
    text predominantly to cytoskeletal fibers but has the potential ability to shuttle between the nucleus and the cytosol.
    basic FUNCTION
  • acting as a negative regulation of transcription
  • may play a critical role in oral carcinogenesis
  • nucleo-cytoplasmic shuttling protein, and its expression is associated with cancer aggressiveness
  • is a microtubule-associated protein that plays a pivotal role in cell proliferation, cell migration, and tumor metastasis
  • is an estrogen receptor (ER) interacting protein that regulates estrogen-mediated breast cancer cell proliferation and tumorigenesis
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text
  • transcription co-repressor
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to PBX1, PBX2
  • is a target of GATA1 and CTCF in erythroid cells and plays an important role in erythroid differentiation by modulating the PI3K/AKT pathway
  • is both a substrate and an inhibitor of APC/C-CDC20 that maintains the temporal stability of cyclin B1 during the G2/M transition and thereby controls mitosis and cell division
  • PRL is a lactogenic hormone that controls pregnancy as well as lactation and induces PBXIP1 expression in a signal transducer and activator of transcription 5a-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer cells
    tumoral     --over  
    in the lung cancer cell lines
    constitutional     --low  
    upon decidualization, in repeated implantation failure (RIF)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PBXIP1 might serve as a novel histological prognostic and regulatory indicator for EMT processes in colorectal cancer that seems to correlate with cancer cell subtypes of high baseline WNT activity
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be a potential therapeutic target for the treatment of ovarian cancer
    cancerlung 
    may be a new therapeutic target for the treatment of lung cancer
    cancerhead and neck 
    is thus a potential target for anticancer therapy in oral squamous cell carcinoma (OSCC), with particular emphasis on its involvement in differentiation and migration/metastasis
    ANIMAL & CELL MODELS