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FLASH GENE
Symbol PBOV1 contributors: - updated : 13-02-2006
HGNC name prostate and breast cancer overexpressed 1
HGNC id 21079
Location 6q23-q24      Physical location : 138.537.128 - 138.539.627
Synonym name UC28 protein
Synonym symbol(s) UC28, UROC28
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     1 Exon(s)    1 Copie(s)
10 Kb 5' upstream gene genomic sequence study
text structure a strong Kozak sequence preceding the ATG initiation codon
MAPPING cloned Y linked N status provisional
Physical map
MAP3K5 6q22.33 mitogen-activated protein kinase kinase kinase 5 PEX7 6q21-q22.2 peroxisomal biogenesis factor 7 SLC35D3 6q23.2 solute carrier family 35, member D3 IL20RA 6q23.3 interleukin 20 receptor, alpha IL22RA2 6q24-q25.1 interleukin 22 receptor, alpha 2 IFNGR1 6q23-q24 interferon gamma receptor 1 OLIG3 6q23.3 oligodendrocyte transcription factor 3 LOC391974 6 similar to RIKEN cDNA 5730434I03 gene LOC134897 6q23.3 similar to protein tyrosine phosphatase TNFAIP3 6q23-q25 tumor necrosis factor, alpha-induced protein 3 PERP 6q24 PERP, TP53 apoptosis effector PBOV1 6q23-q24 prostate and breast cancer overexpressed 1 KIAA1244 6q23.3 KIAA1244 HEBP2 6q24 heme binding protein 2 KIAA1357 6q23.3 KIAA1357 protein LOC389430 6 LOC389430 C6orf80 6q23.1-q24.1 chromosome 6 open reading frame 80 CCRL1P 6q23.3 chemokine (C-C motif) receptor-like 1 pseudogene LOC345930 6q23.3 similar to Ect2 protein REPS1 6q23.1-24.1 RALBP1 associated Eps domain containing 1 C6orf115 6q24.1 chromosome 6 open reading frame 115 HECA 6q23-q24 headcase homolog (Drosophila) C6orf198 6q23.3 chromosome 6 open reading frame 198 CITED2 6q23.3 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 LOC340148 6q23.3 hypothetical LOC340148 LOC391975 6 similar to ATP synthase B chain, mitochondrial precursor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2512 15 135 - An et al
- splicing 2100 15 135 - An et al.
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
Lymphoid/Immunespleen    
 thymus    
Reproductivefemale systemovary   
 male systemtestis   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transmembrane domain
  • three potential phosphorylation sites
  • one potential myristoylation site
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by DHT, in a dose dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate, breast and bladder cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may be a useful target molecule in breast cancer
    ANIMAL & CELL MODELS