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FLASH GENE
Symbol PBK contributors: mct/npt - updated : 30-08-2016
HGNC name PDZ-binding kinase
HGNC id 18282
Location 8p21.1      Physical location : 27.667.139 - 27.695.349
Synonym name
  • MAPKK-like protein kinase
  • serine/threonine protein kinase
  • spermatogenesis-related protein kinase
  • T-LAK cell- originated protein kinase
  • cancer/testis antigen 84
  • T-lymphokine-activated killer cell-originated protein kinase
  • Synonym symbol(s) SPK, NORI3, FLJ14385, Nori-3, TOPK, CT84, HEL164
    EC.number 2.7.12.2
    DNA
    TYPE functioning gene
    STRUCTURE 28.47 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 2128 36.1 322 - 2013 22940854
  • cap site form 1 - variant 1
  • 8 splicing 2102 36.1 333 - 2013 22940854
  • cap site form1 - variant 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphokine activated killer
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    cell cycle     cell cycle
    Text placenta abundantly and fetal kidney, lung, spleen, brain, testis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the characteristic protein kinase subdomains
  • C terminal PDZ-binding T/SXV motif
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • MEK 3/6 related MAPKK
  • CATEGORY enzyme , receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text during mitosis, PBK-Thr-9 was phosphorylated by CDK1/cyclin B and significantly associates with mitotic spindles
    basic FUNCTION
  • mitotic kinase, involved in the activation of lymphoid cells
  • playing a suggested role in the process of spermatogenesis (support testicular functions)
  • plays a role in the formation of spindle midzone and in cytokinesis
  • with MAPK14 are activated in a cell-cycle-dependent manner in neuronal progenitor cells and inhibition of this pathway disrupts progenitor proliferation and self-renewal, a core feature of progenitors (Dougherty 2005)
  • plays an important role in the progenitors, and further implicates the MAPK14 pathway in general, as an important regulator of progenitor proliferation and self-renewal (Dougherty 2005)
  • enhanced expression of PBK may facilitate tumour growth by mediating MAPK14 activation and by helping cells to overcome DNA damage (Ayllon 2007)
  • having a role in augmenting tumor cell growth following transient appearance in different types of progenitor cells (Nandi 2007)
  • mediates promyelocyte proliferation via NFE2L2-regulated cell cycle progression and apoptosis
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction
    signal transduction pathways regulating the cell cycle or cellular proliferation
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • PDZ2 domain of DLG1
  • PBK act as a substrate for CDK1
  • MYC regulates PBK expression through E2F1
  • CHFR ubiquitinates and regulates PBK levels, which is essential for its checkpoint function
  • PBK and PTEN are new players in CHFR mediated mitotic checkpoint
  • NFE2L2 may be a crucial regulator that mediates PBK/TOPK-exerted promotion of cell proliferation
  • cell & other
    REGULATION
    activated by mitotic phosphorylation (phosphorylation required for its kinase activity)
    Other regulated by cell cycle-specific transcription factors E2F and CREB/ATF (Nandi 2007)
    conformational transition of PBK is important for its kinase activity regulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in highly proliferative malignant cells and Burkitt lymphoma
    tumoral     --over  
    in a variety of neoplasms including hematological malignancies (Nandi 2007)
    tumoral     --over  
    highly upregulated in gliomas
    tumoral     --over  
    frequently overexpressed in high-grade lymphomas and its expression is positively correlated to that of MYC and E2F1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high PBK expression, either alone or in combination with a low level of PTEN, may serve as a prognostic marker for lung cancer
  • high PBK/TOPK mRNA/protein expression is specific to human bladder carcinoma and might be used as a novel target for development of cancer immunotherapy and diagnostic biomarker
  • Therapy target PBK-regulated signaling may serve as a potential therapeutic target in colorectal cancer (Zhu 2007)
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    PBK/GPSM2 pathway might be a promising molecular target for treatment of breast cancer
    cancerlung 
    is a potential therapeutic target in lung cancer that promotes cell migration by modulating a PI3K/PTEN/AKT-dependent signaling pathway
    cancerbrainglioma/neuroblstoma
    can be a promising molecular target for glioma treatment
    ANIMAL & CELL MODELS