protein
| TTF1 |
|
interacting with EP300 coactivator (mediating the functional synergism between PAX8 and TTF-1 in thyroid-specific gene expression) |
|
fusion gene PAX8-PPARgamma disrupts normal transcriptional regulation by stimulating some genes and inhibiting others, and may mediate follicular thyroid cell growth and loss of differentiation that ultimately leads to carcinogenesis |
|
binds directly to the TERT and TERC promoters, up-regulating TERT and TERC mRNA, as well as telomerase activity  |
|
interact with the RB1 protein, and thus regulate the cell cycle directly or indirectly  |
|
CDH16 is a novel downstream target of the transcription factor PAX8, likely since the early steps of thyroid development, and its expression is associated with the fully differentiated state of the thyroid cell  |
|
in thyroid cells PAX8 directly binds the Neuropilin-2 promoter leading to its transcriptional repression  |