basic FUNCTION
| molecular transcriptional repressor |
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playing important roles in the normal phenotypic expression of mast cells in association with MITF |
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transactivates the cMyc promoter (Yang 2010) |
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is part of the transcription factor network that regulates the CD8 lineage differentiation of double-positive thymocytes |
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may have an important role as a transcriptional repressor in chromatin remodeling and transcription regulation |
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PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated TP53-dependent pathway and contribute to vascular diseases associated with aging |
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POZ/AT-hook/Kruppel zinc finger (PATZ) transcription factor |
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is able to bind the BCL6 regulatory region, where BCL6 itself acts as a negative regulator, and to contribute to negatively modulate its activity |
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PATZ1 acts as a tumor suppressor in lymphomagenesis by inhibiting BCL6 expression |
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haploinsufficient tumor suppressor role for PATZ1 that would act in lymphomagenesis by down-regulating BCL6 expression |
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PATZ1 is important for Embryonic stem cells (ESCs) pluripotency |
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dosage of PATZ1 modulates reprogramming process via significantly influencing cell senescence, proliferation and chromatin structure |
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regulates several genes involved in cellular adhesion and morphogenesis |
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important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context |
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endothelial PATZ1 potently inhibits endothelial function and angiogenesis via inhibition of FABP4 expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes |