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FLASH GENE
Symbol PASK contributors: mct/npt/pgu - updated : 10-07-2013
HGNC name PAS domain containing serine/threonine kinase
HGNC id 17270
Location 2q37.3      Physical location : 242.045.514 - 242.088.878
Genatlas name paskin
Synonym name
  • PAS-serine/threonine kinase
  • PAS-kinase
  • Synonym symbol(s) STK37, PASKIN, KIAA0135, DKFZP434O051, DKFZp686P2031
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 43.88 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4609 - 1330 - 2001 11459942
    19 - 4741 - 1323 - 2001 11459942
    18 - 4483 - 1288 - 2001 11459942
    18 - 4588 142.92 1323 - 2001 11459942
    - - 4882 - 1143 - 2001 11459942
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunespleen    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Mus musculusmRNA
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two PAS domains (PAS A, and PAS B), PAS domain that also directly binds to and inhibits the catalytic activity of the kinase domain either in cis or in trans, acting potentially as sensors of diverse physical environmental stimuli (light, oxygen partial pressure, and redox potential) and chemical signals
  • ser/thr kinase, catalytic domain
  • HOMOLOGY
    interspecies ortholog to Saccharomyces cerevisiae Psk1 and Psk2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localized in the nuclei of testis germ cells and in the midpiece of sperm tails
    basic FUNCTION
  • ser/thr kinase activity
  • important metabolic sensor in nutrient-sensitive cells and plays an unexpected role in the regulation of key genes involved in maintaining the differentiated phenotype of pancreatic beta cells
  • regulates glycogen synthesis, and has been implicated in glucose-stimulated insulin production in pancreatic beta-cells
  • coordinates glucose utilization in response to cellular energy and metabolic demand
  • coordinates cellular metabolism with metabolic demand
  • protein kinase that bypasses the requirement for activation loop phosphorylation to generate the active kinase conformation
  • involved in the regulation of glucagon secretion by glucose
  • glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity
  • necessary for glucose-responsive transcription of prepro-insulin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • multifunctional eukaryotic translation elongation factor EEF1A1 as a novel interaction partner of PASK (interaction between the PAS A and kinase domains of PASKIN and to the C-terminus of eEF1A1 )
  • cell & other
    REGULATION
    Other regulated by cellular nutrient status
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in autism with deletion 2q37.3
    constitutional     --low  
    in islets from human type 2 diabetic
    Susceptibility to diabetes type MODY
    Variant & Polymorphism other
  • naturally occurring PASK mutation, p.G1117E, may be related to early age-onset diabetes type MODY
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    useful target for the treatment of type 2 diabetes
    ANIMAL & CELL MODELS
  • Mice lacking PASK were resistant to high fat diet-induced lipid accumulation and insulin resistance