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FLASH GENE

Symbol

PARVA

contributors: npt/ - updated : 17-01-2007

HGNC name	parvin, alpha
HGNC id	14652

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.3      Physical location : 12.399.145 - 12.551.410
Synonym name	actopaxin
	matrix-remodelling associated 2
	calponin-like integrin-linked kinase-binding protein
Synonym symbol(s)	FLJ10793, FLJ12254, MXRA2, CH-ILKBP

DNA

TYPE	functioning gene
STRUCTURE	152.27 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	alternatively spliced and alternatively polyadenylated transcripts (Korenbaum 2001)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018222 13 - 3106 NP_060692 - 372 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       highly Nervous nerve cranial nerve     highly Reproductive male system prostate       Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	embryonic development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two calponin homology (CH) domains
	a single alpha-actinin-like-actin-binding domain

HOMOLOGY

interspecies	homolog to murine Parva
	homolog to Drosophila CG12533
	homolog to C.elegans pat-6

intraspecies	paralog to PARVB
	paralog to PARVG

Homologene

FAMILY	parvin family (of focal adhesion proteins)
	alpha actinin superfamily

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	localized to focal adhesions

basic FUNCTION	playing probably a role in the regulation of cell adhesion and cytoskeleton organisation
	actin-binding protein associated with focal contacts

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of focal adhesions

INTERACTION

DNA

RNA

small molecule

protein	binding to actin and paxillin LD1 and LD4 motifs
	with TESK1 (likely regulated by phosphorylation of PARVA, regulates TESK1 activity and subsequent cellular spreading on fibronectin)
	interacting with ILK (mechanically couples integrin and PARVA for mediating cell adhesion)(Fukuda 2009))

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in tumors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS