Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PARVA contributors: npt/ - updated : 17-01-2007
HGNC name parvin, alpha
HGNC id 14652
Location 11p15.3      Physical location : 12.399.145 - 12.551.410
Synonym name
  • actopaxin
  • matrix-remodelling associated 2
  • calponin-like integrin-linked kinase-binding protein
  • Synonym symbol(s) FLJ10793, FLJ12254, MXRA2, CH-ILKBP
    DNA
    TYPE functioning gene
    STRUCTURE 152.27 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text alternatively spliced and alternatively polyadenylated transcripts (Korenbaum 2001)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3106 - 372 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonic development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two calponin homology (CH) domains
  • a single alpha-actinin-like-actin-binding domain
  • HOMOLOGY
    interspecies homolog to murine Parva
    homolog to Drosophila CG12533
    homolog to C.elegans pat-6
    intraspecies paralog to PARVB
    paralog to PARVG
    Homologene
    FAMILY
  • parvin family (of focal adhesion proteins)
  • alpha actinin superfamily
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localized to focal adhesions
    basic FUNCTION
  • playing probably a role in the regulation of cell adhesion and cytoskeleton organisation
  • actin-binding protein associated with focal contacts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of focal adhesions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin and paxillin LD1 and LD4 motifs
  • with TESK1 (likely regulated by phosphorylation of PARVA, regulates TESK1 activity and subsequent cellular spreading on fibronectin)
  • interacting with ILK (mechanically couples integrin and PARVA for mediating cell adhesion)(Fukuda 2009))
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS