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FLASH GENE
Symbol PARVA contributors: npt/ - updated : 17-01-2007
HGNC name parvin, alpha
HGNC id 14652
Location 11p15.3      Physical location : 12.399.145 - 12.551.410
Synonym name
  • actopaxin
  • matrix-remodelling associated 2
  • calponin-like integrin-linked kinase-binding protein
    • Synonym symbol(s) FLJ10793, FLJ12254, MXRA2, CH-ILKBP
    DNA
    TYPE functioning gene
    STRUCTURE 152.27 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1) WEE1 11p15.3 WEE1 homolog (S. pombe) LOC387752 11 similar to 60S ribosomal protein L23a LOC387753 11 similar to 60S ribosomal protein L21 SWAP70 11p15 Homo sapiens SWAP-70 protein (SWAP70), mRNA. CMT4B2 11p15.3 Charcot-Marie-Tooth neuropathy 4B2 (autosomal recessive, with myelin outfolding) ADM 11p15.4 adrenomedullin LOC338749 11p15.3 hypothetical LOC338749 AMPD3 11p15 adenosine monophosphate deaminase (isoform E) RNF141 11p15.3 ring finger protein 141 XLKD1 11p15 extracellular link domain containing 1 MRVI1 11p15 murine retrovirus integration site 1 homolog SH2BP1 11pter-p15.4 SH2 domain binding protein 1 (tetratricopeptide repeat containing) EIF4G2 11p15 eukaryotic translation initiation factor 4 gamma, 2 LOC58486 11p15.3 transposon-derived Buster1 transposase-like protein MGC71806 11p15.3 similar to Hypothetical protein LOC233733 USP47 11p15.2 ubiquitin specific protease 47 RIG 11p15.1 ubiquitin specific protease 47 DKK3 11p15.2 dickkopf homolog 3 (Xenopus laevis) MICAL2 11p15.2 dickkopf homolog 3 (Xenopus laevis) FLJ14966 11p15.3 hypothetical protein FLJ14966 PARVA 11p15.2 parvin, alpha TEAD1 11p15.2 TEA domain family member 1 (SV40 transcriptional enhancer factor) LOC119593 11p15.3 similar to RIKEN cDNA 4632411J06 ARNTL 11p15 aryl hydrocarbon receptor nuclear translocator-like GMRP-1 11p15.3-p15.2 K+ channel tetramerization protein PTH 11p15.2-p15.1 parathyroid hormone FLJ22728 11p15.2 hypothetical protein FLJ22728 LOC338750 11p15.2 similar to hypothetical protein FLJ33167 LOC387754 11 LOC387754 SPON1 11p15.2-p14 spondin 1, (f-spondin) extracellular matrix protein RRAS2 11p15.2 related RAS viral (r-ras) oncogene homolog 2 LOC390094 11 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein COPB 11p15.4-p15.2 coatomer protein complex, subunit beta PSMA1 11p15.1 proteasome (prosome, macropain) subunit, alpha type, 1 PDE3B 11p15.1 phosphodiesterase 3B, cGMP-inhibited MORF4LP3 11p mortality factor 4 like pseudogene 3 CYP2R1 11p15.2 cytochrome P450, family 2, R1 CALCP 11p15.2-p15.1 calcitonin pseudogene CALCA 11p15.2-p15.1 calcitonin/calcitonin-related polypeptide, alpha OR7E41P 11p15 olfactory receptor, family 7, subfamily E, member 41 pseudogene CALCB 11p15.2-p15.1 calcitonin-related polypeptide, beta LOC387755 11 similar to RIKEN cDNA 3830422K02
    RNA
    TRANSCRIPTS type messenger
    text alternatively spliced and alternatively polyadenylated transcripts (Korenbaum 2001)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3106 - 372 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonic development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two calponin homology (CH) domains
  • a single alpha-actinin-like-actin-binding domain
    • HOMOLOGY
    interspecies homolog to murine Parva
    homolog to Drosophila CG12533
    homolog to C.elegans pat-6
    intraspecies paralog to PARVB
    paralog to PARVG
    Homologene
    FAMILY
  • parvin family (of focal adhesion proteins)
  • alpha actinin superfamily
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localized to focal adhesions
    basic FUNCTION
  • playing probably a role in the regulation of cell adhesion and cytoskeleton organisation
  • actin-binding protein associated with focal contacts
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of focal adhesions
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin and paxillin LD1 and LD4 motifs
  • with TESK1 (likely regulated by phosphorylation of PARVA, regulates TESK1 activity and subsequent cellular spreading on fibronectin)
  • interacting with ILK (mechanically couples integrin and PARVA for mediating cell adhesion)(Fukuda 2009))
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS