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FLASH GENE
Symbol PARP3 contributors: mct - updated : 28-06-2011
HGNC name poly (ADP-ribose) polymerase family, member 3
HGNC id 273
Location 3p21.2      Physical location : 51.976.360 - 51.982.881
Synonym name ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3
Synonym symbol(s) ADPRTL3, IRT1, ADPRT3, ADPRTL2, hPARP-3, pADPRT-3
EC.number 2.4.2.30
DNA
TYPE functioning gene
STRUCTURE 6.52 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 2355 60 540 - 2011 21211721
11 splicing 2360 60 533 - 2011 21211721
  • containing an additional segment in the coding region
  • using a downstream start codon, compared to variant 1
  • encoding the same isoform than variant 3
  • - splicing 2490 60 532 - 2011 21211721
  • encoding the same isoform than variant 2
  • containing an additional segment in the coding region
  • using a downstream start codon, compared to variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus  moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the N-terminal domain composed of 54 amino acids is responsible for its centrosomal localization
  • the catalytic domain in the C-terminal region
  • conjugated RiboP , Other
    HOMOLOGY
    interspecies ortholog to murine Adprtl3
    intraspecies homolog to ADPRT
    Homologene
    FAMILY ARTD(PARP) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • core component of the centrosome
  • preferentially localized to the daughter centriole throughout the cell cycle
  • basic FUNCTION
  • ADP-ribosyltransferase (NAD+,poly ADPribose polymerase)-like 3
  • involved in the base excision repair (BER) pathway, by catalysing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism
  • may link the DNA damage surveillance network to the mitotic fidelity checkpoint
  • negatively influences the G1/S cell cycle progression without interfering with centrosome duplication
  • involved in detection/signaling pathway leading to the reparation of DNA strand breaks
  • nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage
  • molecular roles for PARP3 and APLF in chromosomal DNA double-strand break repair reactions (
  • catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory
  • particular role of PARP3 in cellular response to double-strand breaks, most likely in concert with PARP1
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component auto-poly(ADP)-ribosylation
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interaction between PARP1 and PARP3 is unrelated to DNA single-strand break repair
  • interacting with APLF (molecular roles for PARP3 and APLF in chromosomal DNA double-strand break repair reactions)
  • cell & other
    REGULATION
    activated by DNA double-strand breaks (DSBs) and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate chromosomal DNA DSB repair
    induced by DNA breaks
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS