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FLASH GENE
Symbol PARP16 contributors: mct - updated : 21-03-2016
HGNC name poly (ADP-ribose) polymerase family, member 16
HGNC id 26040
Location 15q22.31      Physical location : 65.550.437 - 65.579.018
Synonym symbol(s) C15orf30, FLJ20509, FLJ25281, ARTD15, pART15
EC.number 2.4.2.30
DNA
TYPE functioning gene
STRUCTURE 29.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2551 - 323 - 2012 22701565
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transferase domain likely regulated by effector binding to the adjacent helical domain
  • secondary structure
  • mono(ADP-ribose) transferase with a novel alpha-helical domain that interacts with a catalytic domain loop
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • displays auto-mono(ADP-ribosylation) activity and is affected by canonical poly(ADP-ribose) polymerase inhibitors
  • has ADP-ribose transferase activity, is capable of automodification, and can be inhibited by canonical PARP inhibitors
  • mono-ADP-ribosyltransferase with a new intracellular location, as it is associated with the endoplasmic reticulum
  • appears to have a role in nucleocytoplasmic shuttling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to canonical PARP inhibitors
  • tail-anchored ER transmembrane protein required for activation of the functionally related ER stress sensors EIF2AK3 and ERN1
  • ERN1 signaling is quite context-specific on account of many adaptor and modulator proteins that directly interact with it, including heat shock proteins (HSPs), RNF13, PARP16, TMBIM6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS