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FLASH GENE
Symbol PARM1 contributors: mct - updated : 03-07-2018
HGNC name prostate androgen-regulated mucin-like protein 1
HGNC id 24536
Location 4q13.3      Physical location : 75.858.284 - 75.975.324
Synonym name
  • castration-induced prostatic apoptosis-related protein 1
  • Prostatic androgen-repressed message 1
  • WSC4, cell wall integrity and stress response component 4 homolog (S. cerevisiae)
  • Synonym symbol(s) UNQ1879/PRO4322, Cipar1, DKFZP564O0823, PARM-1, WSC4
    DNA
    TYPE functioning gene
    STRUCTURE 117.03 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 5044 - 310 - 2008 18027867
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Reproductivefemale systemplacenta  highly Homo sapiens
     male systemprostate    Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period ageing
    Text found exclusively in the epithelial cells of involuting prostate
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rat PARM-1 (prostatic androgen-repressed message-1)
    Homologene
    FAMILY
  • PARM family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • type I transmembrane protein
  • in cardiomyocytes, PARM1 is predominantly localized in endoplasmic reticulum (ER)
  • basic FUNCTION
  • involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells
  • may have a role in normal biology of the prostate cell and in prostate cancer
  • is likely involved in the differentiation from the mesodermal lineage to cardiomyocytes
  • novel role of PARM1 in the cardiomyogenic differentiation of stem cells
  • promotes likely cardiomyogenesis through enhancement of cardiac specification but not mesodermal induction
  • PARM1 contributes to ovulation and/or luteal function by acting as a novel regulator of progesterone metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PARM1 may regulate EIF2AK3, ATF6, and DDIT3 expression through BMP2 expression
  • PARM1 increases ERK1/2, but more importantly AKT and STAT3 phosphorylation
  • cell & other
    REGULATION
    Other seems to be regulated by androgens only in the prostate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during regression of the prostate after androgen withdrawal
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker for acquired androgen-independence of these tumor cells
    Marker
    Therapy target
    ANIMAL & CELL MODELS