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FLASH GENE
Symbol PARG contributors: mct - updated : 02-05-2015
HGNC name poly (ADP-ribose) glycohydrolase
HGNC id 8605
Location 10q11.23      Physical location : 51.026.326 - 51.371.331
Synonym name poly(ADP-ribose) glycohydrolase 60 kDa isoform
Synonym symbol(s) RP11-507K13.2, FLJ54459, FLJ60257, FLJ60456, PARG99
EC.number 3.2.1.143
DNA
TYPE functioning gene
STRUCTURE 345.01 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure sharing a 470-bp common promoter region with the inner mitochondrial membrane translocase 23 (TIMM23)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4276 - 976 - 2003 14527731
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
 stomach   highly
Lymphoid/Immunelymph node    
Nervousbrain    
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a regulation domain of 45kDa at the N terminus
  • A REG/MTS site
  • a catalytic domain of 65kDa at the C terminus, that is a distant member of the ubiquitous ADP-ribose-binding macrodomain family
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • in the nucleus during interphase
  • during mitosis, localizes to the cytoplasm, in the centrosome
  • basic FUNCTION
  • poly ADP-ribose glycohydrolase, responsible for rapid turnover for ADP-ribose polymer
  • may play an important role in regulating cell cycle progression and centrosome duplication
  • specific involvement of PARG in the cellular response to oxidative DNA damage
  • is a novel and critical component of SSBR (single-strand break repair) that accelerates this process in concert with PARP1
  • catabolic enzyme that cleaves ADP-ribose polymers synthesized by members of the poly (ADP-ribose) polymerase (PARP) family of enzymes
  • PARP or PARG is associated with the neuronal death in a variety of neurodegenerative diseases
  • PARP1 and PARG regulates various cellular processes in response to genotoxic stress (
  • only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR (Poly(ADP-ribose) chains, and its deficiency leads to cell death
  • probably has influence on ATM/TP53 pathway and metabolic activation of Benzo(a)pyrene
  • removes poly(ADP-ribose) subunits from proteins that have previously been modified by poly(ADP-ribose) polymerase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PCNA, through a PCNA binding site and binding to PCNA contributes to PARG recruitment to DNA damage sites
  • PARG has been thought to be primarily responsible for poly(ADP-ribose) (PAR) degradation
  • cell & other
    REGULATION
    induced by immediately induced by DNA damage
    Other its activity is regulated by interactions of PARP1 and -2 and other proteins at the REG/MTS site
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PARG inhibitors may be used to specifically kill BRCA2 and other homologous recombination-deficient tumors
    ANIMAL & CELL MODELS
  • mouse embryonic fibroblasts carrying a hypomorphic mutation of PARG,(PARG(110)(-/-)), have defects in the repair of DNA damage caused by various genotoxic agents