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FLASH GENE
Symbol PARG contributors: mct - updated : 02-05-2015
HGNC name poly (ADP-ribose) glycohydrolase
HGNC id 8605
Location 10q11.23      Physical location : 51.026.326 - 51.371.331
Synonym name poly(ADP-ribose) glycohydrolase 60 kDa isoform
Synonym symbol(s) RP11-507K13.2, FLJ54459, FLJ60257, FLJ60456, PARG99
EC.number 3.2.1.143
DNA
TYPE functioning gene
STRUCTURE 345.01 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure sharing a 470-bp common promoter region with the inner mitochondrial membrane translocase 23 (TIMM23)
MAPPING cloned Y linked N status provisional
Physical map
GDF2 10q11.22 growth differentiation factor 2 GDF10 10q21.1 growth differentiation factor 10 DKFZP566K0524 10q11.22 DKFZP566K0524 protein LOC387671 10 similar to ARF GTPase-activating protein LOC387672 10 similar to Ribosome biogenesis protein BMS1 homolog LOC387673 10 similar to Glutamate dehydrogenase, mitochondrial precursor (GDH) LOC338598 10q11.22 similar to hypothetical protein MGC5560 LOC118706 10q11.22 similar to ARF GTPase-activating protein LOC387674 10 similar to Ribosome biogenesis protein BMS1 homolog MGC35285 10q11.22 hypothetical protein MGC35285 MAPK8 10q11.2 mitogen-activated protein kinase 8 RhoGAP2 LOC387675 10 LOC387675 LOC159491 LOC389964 10 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein KIAA1607 FLJ31737 LOC170370 10q11.23 hypothetical LOC170370 LOC170371 10q11.23 hypothetical protein LOC170371 LOC118461 DRG11 ERCC6 10q11 excision repair cross-complementing rodent repair deficiency, complementation group 6 PGBD3 10q11 piggyBac transposable element derived 3 CHAT 10q11.2 choline acetyltransferase SLC18A3 10q11.2 solute carrier family 18 (vesicular acetylcholine), member 3 LOC282966 10q11.23 hypothetical protein LOC282966 FLJ10851 10q11.23 hypothetical protein FLJ10851 MAPK6PS6 10q11.21 hypothetical protein FLJ10851 PARG 10q11.23 poly (ADP-ribose) glycohydrolase LOC387676 10 similar to KIAA0592 protein LOC387677 10 hypothetical gene supported by BC051717; NM_133446 LOC255319 10q11.23 similar to ARF GTPase-activating protein MSMB 10q11.2 microseminoprotein, beta- NCOA4 10q11.2 nuclear receptor coactivator 4 TIMM23 10q11.21-q11.23 translocase of inner mitochondrial membrane 23 homolog (yeast) LOC387678 10 similar to ARF GTPase-activating protein LOC389965 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC387679 10 similar to KIAA0592 protein LOC387680 10 similar to KIAA0592 protein LOC389966 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) ASAH2 10q11.21 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 LOC387681 10 hypothetical gene supported by BT007130; NM_001378 MOB 10q11.2 mob protein LOC340858 10q21.1 similar to hypothetical protein FLJ10539 FLJ31958 10q21.1 hypothetical protein FLJ31958 LOC389967 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC389968 10 similar to Cathepsin L preproprotein LOC283023 10q21.1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) ACF 10q21,1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) PRKG1 10q11.2 protein kinase, cGMP-dependent, type I
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4276 - 976 - 2003 14527731
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
 stomach   highly
Lymphoid/Immunelymph node    
Nervousbrain    
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a regulation domain of 45kDa at the N terminus
  • A REG/MTS site
  • a catalytic domain of 65kDa at the C terminus, that is a distant member of the ubiquitous ADP-ribose-binding macrodomain family
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • in the nucleus during interphase
  • during mitosis, localizes to the cytoplasm, in the centrosome
  • basic FUNCTION
  • poly ADP-ribose glycohydrolase, responsible for rapid turnover for ADP-ribose polymer
  • may play an important role in regulating cell cycle progression and centrosome duplication
  • specific involvement of PARG in the cellular response to oxidative DNA damage
  • is a novel and critical component of SSBR (single-strand break repair) that accelerates this process in concert with PARP1
  • catabolic enzyme that cleaves ADP-ribose polymers synthesized by members of the poly (ADP-ribose) polymerase (PARP) family of enzymes
  • PARP or PARG is associated with the neuronal death in a variety of neurodegenerative diseases
  • PARP1 and PARG regulates various cellular processes in response to genotoxic stress (
  • only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR (Poly(ADP-ribose) chains, and its deficiency leads to cell death
  • probably has influence on ATM/TP53 pathway and metabolic activation of Benzo(a)pyrene
  • removes poly(ADP-ribose) subunits from proteins that have previously been modified by poly(ADP-ribose) polymerase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PCNA, through a PCNA binding site and binding to PCNA contributes to PARG recruitment to DNA damage sites
  • PARG has been thought to be primarily responsible for poly(ADP-ribose) (PAR) degradation
  • cell & other
    REGULATION
    induced by immediately induced by DNA damage
    Other its activity is regulated by interactions of PARP1 and -2 and other proteins at the REG/MTS site
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PARG inhibitors may be used to specifically kill BRCA2 and other homologous recombination-deficient tumors
    ANIMAL & CELL MODELS
  • mouse embryonic fibroblasts carrying a hypomorphic mutation of PARG,(PARG(110)(-/-)), have defects in the repair of DNA damage caused by various genotoxic agents