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FLASH GENE
Symbol PARD3B contributors: mct/npt - updated : 07-09-2016
HGNC name par-3 partitioning defective 3 homolog B (C. elegans)
HGNC id 14446
Location 2q33.3      Physical location : 205.410.515 - 206.480.537
Synonym name
  • partitioning-defective 3-like
  • cell polarity protein PAR3
  • amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19
  • partitioning-defective 3-like
  • PAR3-L protein
  • Synonym symbol(s) PAR3L, PAR3B, ALS2CR19, MGC16131, PAR3LC, PAR3beta, Par3Lb
    DNA
    TYPE functioning gene
    STRUCTURE 1074.37 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 splicing 3522 132.5 1104 - 2005 15721295
    22 splicing 3639 126.1 1143 - 2005 15721295
    also called PAR3B
    22 splicing 3618 124.9 1136 - 2005 15721295
    23 - 8174 - 1205 - 2005 15721295
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   predominantly
    Urinarykidneynephronrenal capsuleglomerulushighly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines colon and renal tumor cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a region homologous to the aPKC-binding domain of PAR3alpha
  • three PDZ domains, the first PDZ domain of PAR3alpha is considered to interact with PAR6
  • HOMOLOGY
    intraspecies homolog to PARD3
    Homologene
    FAMILY
  • PAR3 family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • PARD3B localize to tight junctions of epithelial cells
  • basic FUNCTION
  • may be acting as an inducible transporter in the biliary and intestinal excretion of organic anions
  • PARD3 and PARD3B participate in cell polarity establishment and localize to tight junctions of epithelial cells
  • PARD3, PARD3B, atypical protein kinase C (aPKC) and PARD6A, PARD6B critically regulate the apical membrane development required for epithelial organ development (Horikoshi 2009)
  • interaction with STK11 is key for the function of PARD3B in mammary stem cell maintenance
  • dominant gene expressed in podocytes and found at the basis of the slit diaphragm, where it partially colocalizes with podocin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with PAR6, PARD3 and PRKDZ (atypical ptotein kinase C)
  • complexing with PAR6 and atypical protein kinase C (aPKC), and the protein complex
  • binding to INSC
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to PARD6A
  • PARD3 and PARD3B interacts with 14-3-3 proteins in a phosphorylation-dependent manner
  • PARD3B binds to the tumour suppressor protein STK11 and inhibits its kinase activity
  • cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PARD3
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • PARD3B localize to tight junctions of epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS