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FLASH GENE
Symbol PAQR8 contributors: npt - updated : 13-01-2010
HGNC name progestin and adipoQ receptor family member VIII
HGNC id 15708
Location 6p12.2      Physical location : 52.226.925 - 52.272.574
Synonym name
  • lysosomal membrane protein in brain-1
  • chromosome 6 open reading frame 33
  • membrane progestin receptor beta
  • Synonym symbol(s) LMPB1, FLJ32521, MPRB, C6orf33, FLJ46206
    DNA
    TYPE functioning gene
    STRUCTURE 45.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located in the candidate region harboring a gene for EJM1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4758 - 354 - Zhu (2003)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  moderately
    Nervousbrain   moderately
    Reproductivemale systemtestis  moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular N terminus
  • an intracellular C terminus
  • seven transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Paqr8
    Homologene
    FAMILY
  • ADIPOR family
  • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • integral to membrane
  • colocalizes with a lysosomal protein cathepsin D
  • basic FUNCTION
  • involved in specialized lysosomal function (unique to brain and testis )
  • acting as a steroid membrane receptor
  • may be involved in oocyte maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text oocyte maturation
    PATHWAY
    metabolism
    signaling signal transduction
    G-protein coupled receptor protein signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • progesterone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS