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FLASH GENE
Symbol PAQR3 contributors: mct - updated : 09-02-2012
HGNC name progestin and adipoQ receptor family member III
HGNC id 30130
Location 4q21.21      Physical location : 79.839.093 - 79.860.582
Synonym name Raf kinase trapping to Golgi
Synonym symbol(s) RKTG
DNA
TYPE functioning gene
STRUCTURE 21.49 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3739 - 311 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveintestinelarge intestinecolon highly
 mouthtongue  moderately
Reproductivemale systemtestis  moderately
Urinarybladder   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus interacts with G beta and tethers G betagamma to the Golgi apparatus , facing the cytosol
  • multiple sequences are responsible for its localization at the Golgi apparatus and RAF1 interaction
  • first discovered Golgi protein with seven transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Paqr3
    ortholog to rattus Paqr3_predicted
    Homologene
    FAMILY
  • PAQR (Progestin and AdipoQ Receptors) family
  • CATEGORY regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • integral to membrane
  • located at the Golgi apparatus
  • basic FUNCTION
  • acts as a spatial regulator of Raf kinase by sequestering Raf to the Golgi apparatus, thereby antagonizing the mitogen-activated protein kinase (Raf/MEK/ERK) signaling cascade
  • may play a suppressive role in melanoma that harbors an oncogenic BRAF mutation via its antagonistic action on BRAF
  • functions as a spatial regulator of RAF1 kinase by sequestrating RAF1 to the Golgi
  • inhibits G betagamma- and ligand-mediated AKT phosphorylation that is enhanced in cells with downregulation of PAQR3
  • can modulate GPCR signaling through sequestering G betagamma to the Golgi apparatus and thereby attenuating the functions of G betagamma
  • negative regulator of mitogen-activated protein kinase (Raf/MEK/ERK) signaling, by sequestration of Raf kinase to the Golgi apparatus, in angiogenesis and clear-cell renal cell carcinoma
  • likely implicated in the development of clear-cell renal cell carcinoma through its regulation on angiogenesis
  • spatial regulator of Raf kinase, in VEGF-mediated signaling and angiogenesis
  • can inhibit HIF1A- and hypoxia-stimulated VEGF expression and such inhibition is mediated by the Raf/MEK/ERK signaling pathway
  • promotes SCAP/SREBF complex formation, potentiates SREBF processing and enhances lipid synthesis
  • regulates cholesterol homeostasis by anchoring SCAP/SREBF to the Golgi and disruption of such function reduces cholesterol biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between PAQR3 and adiponectin may help explain the antiproliferative properties of adiponectin
  • PAQR3 interacts with SCAP and SREBF and tethers them to the Golgi
  • cell & other
    REGULATION
    repressed by adiponectin that functions as an agonist of PAQR3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in clinical clear-cell renal cell carcinoma, with an inverse correlation with VEGF expression level
    constitutional   deletion    
    can enhance VEGF-induced angiogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS