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FLASH GENE
Symbol PAPSS1 contributors: mct/npt - updated : 08-10-2018
HGNC name 3'-phosphoadenosine 5'-phosphosulfate synthase 1
HGNC id 8603
Location 4q25      Physical location : 108.534.822 - 108.641.419
Synonym symbol(s) ATPSK1, SK1, PAPSS
EC.number 2.7.1.25, 2.7.7.4
DNA
TYPE functioning gene
STRUCTURE 106.60 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2558 - 624 - Shih (2009)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Lymphoid/Immunethymus    
Nervousbrain   highly
Reproductivefemale systemovary   
 male systemprostate   
Skin/Tegumentskin   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal APS kinase domain (approximately 1-260 AA)
  • a C-terminal ATP sulfurylase domain (approximately 220-623 AA)
  • HOMOLOGY
    intraspecies homolog to PAPSS2 (77 p100)
    Homologene
    FAMILY
  • APS kinase family and sulfate adenylyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • PAPSS1 was predominantly nuclear, whereas PAPSS2 localised mainly within the cytoplasm
  • basic FUNCTION
  • bifunctional enzyme with both ATP sulfurylase and APS kinase activity, mediating two steps in the sulfate activation pathway
  • involved in the biosynthesis of sulfated l-selectin ligands in endothelial cells
  • catalyzes two subsequent reactions starting from ATP and sulfate (Harjes 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed with PAPSS2
  • role for CIB1 in neoplastic transformation, revaeling a novel mechanism facilitating oncogenic signalling by HRAS and PAPSS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to hepatocellular carcinoma in hepatitis B carriers (Shih 2009)
    Variant & Polymorphism other
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS