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FLASH GENE
Symbol PAPOLG contributors: npt - updated : 19-07-2006
HGNC name poly(A) polymerase gamma
HGNC id 14982
Location 2p15      Physical location : 60.983.364 - 61.029.220
Synonym name
  • SRP RNA 3' adenylating enzyme/PAP2
  • polynucleotide adenylyltransferase gamma
  • neo-poly(A) polymerase
  • Synonym symbol(s) PAP2, PAPG, SRPRNA, FLJ12972, FLJ11805, FLJ13482, FLJ14187, MGC133307, MGC133308
    EC.number 2.7.7.19
    DNA
    TYPE functioning gene
    STRUCTURE 42.72 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FANCL 2p16.1 Fanconi anemia, complementation group L LOC339799 2p16.1 similar to eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD); eIF3-epsilon LOC151443 2p16.1 hypothetical LOC151443 LOC151445 2p16.1 similar to IK cytokine; arginine/glutamic acid/aspartic acid repeat containing protein LOC130839 2p16.1 hypothetical gene LOC130839 BCL11A 2p15 B-cell CLL/lymphoma 11A (zinc finger protein) LOC130865 2p16.1 similar to 60S RIBOSOMAL PROTEIN L26 ATP1B3P1 2p13-p15 ATPase, Na+/K+ transporting, beta 3 pseudogene PAPOLG 2p15 poly(A) polymerase gamma REL 2p12 v-rel reticuloendotheliosis viral oncogene homolog (avian) LOC344423 2p16.1 similar to ribosomal protein S12 FLJ32312 2p16.1 hypothetical protein FLJ32312 PEX13 2p16-p14 peroxisome biogenesis factor 13 KIAA1841 2q14 KIAA1841 protein LOC339804 2p16.1 hypothetical gene supported by AK075484; BC014578 AHSA2 2p16.1-p15 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) USP34 2p14 ubiquitin specific protease 34 XPO1 2p16 exportin 1 (CRM1 homolog, yeast) LOC391376 2 similar to 60S ribosomal protein L14 (CAG-ISL 7) FLJ13305 2p15 hypothetical protein FLJ13305 CCT4 2p13.3 chaperonin containing TCP1, subunit 4 (delta) C2orf5 2p15 chromosome 2 open reading frame 5 (MURR1) LOC388954 2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) B3GNT1 2p14 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 FLJ34583 KIAA0903 2p15 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 OTX1 2p13 orthodenticle homolog 1 (Drosophila) LOC51057 2p15 hypothetical protein LOC51057
    RNA
    TRANSCRIPTS type messenger
    text displaying distinct mRNA splice varaints (Topalian)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4252 82.8 736 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved cyclin recognition motif
  • a multiple potential cyclin-dependent kinase (Cdk) phosphorylation sites
  • a U1A protein-interacting region in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • poly (A) polymerase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polynucleotide adenylyltransferase
  • catalyzing template-independent (adenylation) extension of the 3' end of a DNA/RNA strand
  • exhibiting both non specific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA processing,mRNA polyadenylation
    PATHWAY
    metabolism
    signaling
    a component
  • component of pre RNA polyadenylation complex
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • U1A protein
  • cell & other
    REGULATION
    inhibited by U1A protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS