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FLASH GENE
Symbol PAPOLB contributors: KTN/npt - updated : 25-08-2008
HGNC name poly(A) polymerase beta (testis specific)
HGNC id 15970
Location 7p22.1      Physical location : 4.897.370 - 4.901.625
Synonym name
  • testis-specific poly(A) polymerase
  • polynucleotide adenylyltransferase beta
  • apolymerase
  • Synonym symbol(s) PAPT, TPAP, PAP-beta
    EC.number 2.7.7.19
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless
    MAPPING cloned Y linked N status confirmed
    Physical map
    SRPK2 7q22 SFRS protein kinase 2 KIAA0415 7p22.2 KIAA0415 gene product FLJ10324 7p22 hypothetical protein FLJ10324 RABGEF1 7q11.21 RAB guanine nucleotide exchange factor (GEF) 1 PAPOLB 7p22.2 poly(A) polymerase beta (testis specific) PAQR10 7p22.2 progestin and adipoQ receptor family member X LOC392741 7 LOC392741 LOC392972 7 similar to hypothetical protein LOC392858 7 similar to hypothetical protein FLJ10307 LOC392936 7 similar to ribosomal protein L31 FLJ10099 7q11.22 hypothetical protein FLJ10099 RBAK 7p22.2 hypothetical protein FLJ10099 LOC221937 7p22.2 forkhead box K1 LOC392622 7 hypothetical gene supported by BC031661 SBDS 7q11.21 Shwachman-Bodian-Diamond syndrome FLJ10900 7q11.22 hypothetical protein FLJ10900 FLJ20485 7q22.2 hypothetical protein FLJ20485 LOC392859 7 similar to olfactory receptor MOR267-3 LOC285924 7p22.2 hypothetical protein LOC285924 KIAA0415 7p22.2 KIAA0415 gene product FLJ11785 7q22.2 Rad50-interacting protein 1 FLJ10324 7p22 hypothetical protein FLJ10324 DKFZP434J154 7p22.2 DKFZP434J154 protein LOC392773 7 hypothetical gene supported by M24070; NM_004559 PAPOLB 7p22.2 poly(A) polymerase beta (testis specific) LOC392774 7 similar to KIAA1218 protein SLC29A4 7p22.2 solute carrier family 29 (nucleoside transporters), member 4 PAQR10 7p22.2 progestin and adipoQ receptor family member X KIAA1856 7p22.2 KIAA1856 protein LOC391996 7 similar to hypothetical protein FLJ10307 LOC392712 7 similar to Williams-Beuren syndrome critical region protein 19 LOC392713 7 similar to PMS4 homolog mismatch repair protein - human FLJ13195 7p11.2-q11.2 hypothetical protein FLJ13195 similar to stromal antigen 3 MGC33190 7q22.2 hypothetical protein MGC33190 LOC392623 7 LOC392623 FLJ11467 7p22.2 hypothetical protein FLJ11467 RBAK 7p22.2 hypothetical protein FLJ11467 LOC389458 7 hypothetical gene supported by BC031661 LOC391997 7 similar to olfactory receptor MOR267-3 LOC285924 7p22.2 hypothetical protein LOC285924 ACTB 7p22 actin, beta LOC392860 7 similar to Calgizzarin (S100C protein) (MLN 70) LOC392945 7 similar to 60S ribosomal protein L10 (QM protein homolog) DKFZP434J154 7p22.2 DKFZP434J154 protein FSCN1 7p22 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) GNAI1 7q21.3-q22.1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 TRIAD3 7p22.2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 FLJ23834 7q22.2 hypothetical protein FLJ23834
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4271 71 637 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a poly-A related domain
  • HOMOLOGY
    interspecies homolog to rattus Papolb (87.3 pc)
    homolog to murine Papolb (87 pc)
    Homologene
    FAMILY poly(A) polymerase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polynucleotide adenylyltransferase,governing germ cell morphogenesis by modulating specific transcription factors at posttranscriptional and posttranslational levels
  • regulating spermatogenesis
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA processing;mRNA polyadenylation
    PATHWAY
    metabolism
    signaling
    a component component of pre RNA polyadenylation complex
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with GSG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS