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FLASH GENE
Symbol PAPOLB contributors: mct - updated : 07-04-2021
HGNC name poly(A) polymerase beta (testis specific)
HGNC id 15970
Location 7p22.1      Physical location : 4.897.370 - 4.901.625
Synonym name
  • testis-specific poly(A) polymerase
  • polynucleotide adenylyltransferase beta
  • apolymerase
  • Synonym symbol(s) PAPT, TPAP, PAP-beta
    EC.number 2.7.7.19
    DNA
    TYPE functioning gene
    STRUCTURE 4.29 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4293 71 637 - 2001 11459229
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a poly-A related domain
  • HOMOLOGY
    interspecies homolog to rattus Papolb (87.3 pc)
    homolog to murine Papolb (87 pc)
    Homologene
    FAMILY poly(A) polymerase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • polynucleotide adenylyltransferase,governing germ cell morphogenesis by modulating specific transcription factors at posttranscriptional and posttranslational levels regulating spermatogenesis
  • testis-specific cytoplasmic poly(A) polymerase PAPOLB is essential for spermatogenesis
  • PAPOLB regulates spermatogenesis through its adenylation activity
  • PAPOLB may likely regulate spermiogenesis through a pathway distinct from that mediated by chromatoid body (CB)-associated factors
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    text mRNA processing;mRNA polyadenylation
    PATHWAY
    metabolism
    signaling
    a component component of pre RNA polyadenylation complex
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with GSG1
  • BNC1 role in spermatogenesis by directly binding to BNC1 binding elements in the promoter regions of both YBX2 and PAPOLB and inducing transcription of these important spermatogenesis genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mutant mice lacking a testis-specific cytoplasmic poly(A) polymerase, Papolb, exhibit spermiogenesis arrest and male infertility