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FLASH GENE
Symbol PAPOLA contributors: - updated : 27-09-2004
HGNC name poly(A) polymerase alpha
HGNC id 14981
Location 14q32.1-q32.2      Physical location : 96.968.719 - 97.033.446
Synonym symbol(s) PAP, PLAP
EC.number 2.7.7.19
DNA
TYPE functioning gene
STRUCTURE 30.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nucleotidyl transferase domain
  • a U1A interacting domain in the C terminus
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Pap
    Homologene
    FAMILY poly (A) polymerase family
    CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text the 90kDa isoform is nuclear,the 100kDa is cytoplasmic and nuclear
    basic FUNCTION
  • polynucleotide adenylyltransferase
  • adenosine addition reaction,CPSF dependent
  • required for endoribonucleolytic cleavage reaction at some poly (A) sites
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text mRNA processing,mRNA polyadenylation
    PATHWAY
    metabolism
    signaling
    a component component of pre RNA polyadenylation complex
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein U1A protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS