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FLASH GENE
Symbol PAPD7 contributors: mct/pgu - updated : 21-08-2013
HGNC name PAP associated domain containing 7
HGNC id 16705
Location 5p15.31      Physical location : 6.714.717 - 6.757.161
Synonym name
  • topoisomerase-related function protein 4-1
  • polymerase (DNA directed) sigma
  • TUTase 5
  • terminal uridylyltransferase 5
  • Synonym symbol(s) LAK1, POLK, TRF4-1, TRF4, LAK-1, POLS, TRF41, TUTASE5
    EC.number 2.7.7.7
    DNA
    TYPE functioning gene
    STRUCTURE 43.09 kb     13 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3871 62 542 - 2013 23376078
  • PAPD7s
  • lacks N-terminal residues evenly distributed throughout the cell
  • exhibits not nucleotidyl transferase activity
  • 13 - 3868 - 541 - 2013 23376078
    - - 3473 - 362 - 2013 23376078
    - - - 94 - localizes to the nucleoplasm 2013 23376078
  • 230 extra AAs at the N-terminus, with a nuclear export signal (NES) in AAs 1–166
  • a region required for the activity was localized to 187–219 AA, and this region was also required for the nuclear retention of PAPD7l
  • is the major and active isoform of PAPD7 expressed in cells
  • exhibits a robust nucleotidyl transferase activity compared with the 62 kDa isoform
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   moderately
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nucleotidyltransferase domain
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae DNA polymerase kappa
    homolog to yeast S.cerevisiae trf4
    homolog to rattus Pols (94.5 pc)
    homolog to murine Pols (94.7 pc)
    intraspecies homolog to PAPD5
    Homologene
    FAMILY
  • nucleotidyltransferase family
  • DNA polymerase type-B-like family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • mainly localized to the nucleus, however, in sharp contrast to PAPD5, it was excluded from the nucleolus and weak staining was detected in the cytoplasm
  • basic FUNCTION
  • acting as a DNA polymerase involved in DNA repair
  • may play a role in sister chromatid cohesion
  • play a role in DNA repair and cell cycle regulation
  • functions mainly in the nucloplasm, and also has roles in the cytoplasm
  • PAPD7 and/or PAPD5 are potentially also involved in the pre-mRNA processing in the nucleoplasm
  • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide, chromatin organization
    nucleotide, replication
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text
  • double-strand break repair (repair of camptothecin DNA damage)
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by cell-cycle regulated at a post-transcriptional level
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS