Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PAPD4 contributors: mct/npt - updated : 12-07-2013
HGNC name PAP associated domain containing 4
HGNC id 26776
Location 5q14.1      Physical location : 78.908.242 - 78.982.471
Synonym name
  • GLD-2 poly(A) polymerase
  • TUTase 2
  • poly(A) RNA polymerase GLD2
  • terminal uridylyltransferase 2
  • Synonym symbol(s) FLJ38499, GLD2, GLD-2
    EC.number 2.7.7.19
    DNA
    TYPE functioning gene
    STRUCTURE 74.23 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1-3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3523 56 484 - 2004 15070731
    16 - 3248 56 484 - 2004 15070731
    16 - 3282 56 484 - 2004 15070731
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • DNA polymerase type-B-like family
  • GLD2 subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in synaptic translation, and in polyadenylation throughout the soma
  • responsible for poly(A) tail lengthening and hence translational control
  • playing a role in synaptic regulation
  • has a role in long-term memory
  • may potentially act in the ooplasm on the progression of metaphase I to metaphase II during oocyte maturation
  • MTPAP, PAPD4, PAPD5, ZCCHC6, ZCCHC11, and TUT1, were found to govern 3prime nucleotide addition to miRNAs in a miRNA-specific manner
  • ZCCHC6, ZCCHC11, and PAPD4 are the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation
  • directly monoadenylates and stabilizes specific miRNA populations in human fibroblasts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the miRNA biogenesis pathway with ZCCHC6, ZCCHC11
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the polyadenylation factor, CPEB1, in a conserved manner
  • interacts with eIF4E and FMR1 proteins
  • ultimate target of the Aurora kinase/Maskin/CPEB1 regulatory pathway and is acutely required during the period of long-term memory formation
  • CPEB1 and PAPD4 are antagonizing factors regulating TP53 mRNA stability
  • QKI recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in livers from Papd4-null mice, the steady-state level of the mature form of MIR122 was specifically lower than in heterozygous mice, whereas no reduction of pre-MIR122 by Papd4 is required for the selective stabilization of MIR122 in the liver