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FLASH GENE

Symbol

PANX2

contributors: mct/npt - updated : 06-03-2010

HGNC name	pannexin 2
HGNC id	8600

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.33      Physical location : 50.609.159 - 50.618.723
Synonym symbol(s)	HPANX2, XP2, MGC119432

DNA

TYPE	functioning gene
STRUCTURE	9.56 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_052839 3 - 3069 NP_443071 - 677 - Baranova, Lai (2009) also called: PANX2 alt2 an additional exon A NM_001160300 - - 2984 NP_001153772 - 643 - Baranova, Lai (2009) also called: PANX2 alt1

EXPRESSION

Rna function	PANX2 mRNA is detected only in postnatal tissue, and in the hippocampus, mRNA levels increase during the peak period of granule cell neurogenesis
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea   highly Nervous brain limbic system hippocampus   predominantly Homo sapiens   spinal cord       predominantly Homo sapiens Urinary kidney         Visual eye lens     highly   eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central     predominantly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

pannexin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,vesicle
text	predominantely detected in the cytoplasm in vesicle-like patterns but not at the plasma membrane (Lai 2009)
	localizing to Golgi and endoplasmic reticulum membranes

basic FUNCTION	contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers (Dvoriantchikova 2006)
	like connexins, may play an important role in hearing (Wang 2009)
	PANX2 protein expression plays a role in regulating the timing of neuronal differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	strongly interacts with the core and high-mannose species of PANX1 but not with PANX3 (Penuela 2009)
	physically interacts with PANX1 to reduce current amplitude

cell & other

REGULATION

Other	regulated by glycosylation (regulates pannexin intermixing and cellular localization) (Penuela 2009)
	endogenous post-translational regulation, specific to early neural progenitor cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrant expression during gliomagenesis (Lai 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS