Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PANK4 contributors: - updated : 28-01-2006
HGNC name pantothenate kinase 4
HGNC id 19366
Location 1p36.32      Physical location : 2.439.974 - 2.458.035
Synonym name pantothenic acid kinase
Synonym symbol(s) HGNC19368, DKFZp547M242, FLJ10782
EC.number 2.7.1.33
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     18 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
text structure six exons for the core protein
MAPPING cloned Y linked N status provisional
Physical map
LOC388775 1 similar to testis-specific protein NYD-TSP1 MRPL20 1p36.3-36.2 mitochondrial ribosomal protein L20 LOC391207 1 LOC391207 LOC388582 1 LOC388582 WARP 1p36.33 von Willebrand factor A domain-related protein FLJ37183 1p36.33 FLJ37183 protein TOB3 1p36.33 FLJ37183 protein FLJ10709 1p36.33 hypothetical protein FLJ10709 TLR5 1q33.3 toll-like receptor 5 LOC339453 1p36.33 hypothetical LOC339453 HSPC182 1p36.33 HSPC182 protein MMP23A 1p36.3 matrix metalloproteinase 23A SLC35E2 1p36.33 solute carrier family 35, member E2 FLJ13052 1p36.33-p36.21 NAD kinase GNB1 1p36.2 guanine nucleotide binding protein (G protein), beta polypeptide 1 LOC388583 1 similar to hypothetical protein LOC339457 PRKCZ 1p36.33-p36.2 protein kinase C, zeta FLJ31031 1p36.32 hypothetical protein FLJ31031 FLJ14100 1p36.32 hypothetical protein FLJ14100 SKI 1p36.3 v-ski sarcoma viral oncogene homolog (avian) LOC388584 1 LOC388584 FLJ13941 1p36.32 hypothetical protein FLJ13941 RER1 1pter-q24 RER1 homolog (S. cerevisiae) PEX10 1p36.33 peroxisome biogenesis factor 10 KIAA0450 1p36.32 peroxisome biogenesis factor 10 PANK4 1p36.32 pantothenate kinase 4 LOC388585 1 similar to hairy and enhancer of split 5 LOC388586 1 LOC388586 TNFRSF14 1p36.3-p36.22 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) MGC26818 1p36.32 hypothetical protein MGC26818 MMEL2 1p36 membrane metallo-endopeptidase-like 2 LOC390988 1 similar to RIKEN cDNA B230396O12 LOC390989 1 LOC390989 ARPM2  actin-related protein M2 DKFZp761G0122 1p36.32 hypothetical protein DKFZp761G0122 LOC148872 1p36.32 LOC148872 protein PRDM16 1p36.23-p33 PR domain containing 16 ARHGEF16 1p36.32 Rho guanine exchange factor (GEF) 16 EGFL3 1p36.3 EGF-like-domain, multiple 3 LOC388587 1 LOC388587 LOC127262 1p36.32 hypothetical protein LOC127262 WDR8 1p36.3 WD repeat domain 8
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebonesubchondral  
Connectivebone   
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • long Cterminus with DUF 89 domain
  • HOMOLOGY
    Homologene
    FAMILY pantothenate kinase family.
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • first committed step of universal CoA biosynthesis . catalyzing the phospharylation of pantothenate (vitamin B5) and derivatives
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism vitamin
    signaling
    regulatory enzyme in CoA biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS