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FLASH GENE
Symbol PAM contributors: mct - updated : 22-02-2008
HGNC name peptidylglycine alpha-amidating monooxygenase
HGNC id 8596
Location 5q14-q21      Physical location : 102.201.526 - 102.366.806
Synonym name
  • pancreatic peptidylglycine alpha-amidating monooxygenase
  • peptidyl-alpha-hydroxyglycine alpha-amidating lyase
  • peptidylglycine 2-hydroxylase
  • Synonym symbol(s) PAL, PHM
    EC.number 1.14.17.3
    DNA
    TYPE functioning gene
    STRUCTURE 163.00 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    ARTS-1 5q15 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator LRAP 16 leukocyte-derived arginine aminopeptidase FLJ39485 5q15 hypothetical protein FLJ39485 LNPEP 5q21 leucyl/cystinyl aminopeptidase FLJ25534 5q15 hypothetical protein FLJ25534 RIOK2 5q14 RIO kinase 2 (yeast) LOC391812 5 similar to Dermatomyositis associated with cancer putative autoantigen-1 (DACA-1) LOC391813 5 similar to Zinc finger DHHC domain containing protein 3 (Zinc finger protein 373) (DHHC1 protein) LOC389312 5 similar to Proteasome activator complex subunit 2 (Proteasome activator 28-beta subunit) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex beta subunit) (REG-beta) LOC391814 5 similar to cytoplasmic beta-actin MRPS35P2 5q15 mitochondrial ribosomal protein S35 pseudogene 2 LOC285703 5q21.1 similar to C-terminal binding protein 2 isoform 2; ribeye LOC391815 5 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) FLJ90406 CHD1 5q15-q21 chromodomain helicase DNA binding protein 1 LOC389313 5 LOC389313 LOC256055 5q21.1 similar to Beta-glucuronidase precursor (Beta-G1) LOC285706 5q21.1 cytokine receptor-like factor 3 pseudogene LOC389314 5 similar to NADH dehydrogenase subunit 5 LOC389315 5 LOC389315 UNQ1912 5q21.1 HGS_RE408 SIAT8D 5p21 sialyltransferase 8D (alpha-2, 8-polysialyltransferase) SLCO4C1 5q21.2 solute carrier organic anion transporter family, member 4C1 SLCO6A1 5q21.2 solute carrier organic anion transporter family, member 6A1 PAM 5q15 peptidylglycine alpha-amidating monooxygenase LOC134505 5q21.2 similar to eukaryotic translation initiation factor 3 subunit k; muscle specific gene FLJ20125 5q21.2 hypothetical protein FLJ20125 KIAA0433 5q21-q23 hypothetical protein FLJ20125 LOC90355 5q21.2 hypothetical gene supported by AF038182; BC009203 LOC345761 5q21.3 similar to 2610034M16Rik protein NUDT12 5q15 nudix (nucleoside diphosphate linked moiety X)-type motif 12 RAB9P1 5q14.3-q15 RAB9, member RAS oncogene family, pseudogene 1 LOC345571 5q21.3 similar to rap2 interacting protein x LOC391817 5 similar to protease (prosome, macropain) 26S subunit, ATPase 1 EFNA5 5q21 ephrin-A5 LOC391818 5 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) LOC345576 5q21.3 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) FBXO13 5q21.3 F-box only protein 13 RPS20P3 5q13-q23 ribosomal protein S20 pseudogene 3 FER 5q21 fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3960 - 974 - Olsen (2006)
    24 - 3753 - 905 - Olsen (2006)
    24 - 3636 - 866 - Olsen (2006)
    23 - 3699 - 887 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     parathyroid   highly
    Hearing/Equilibriumear   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • catalyzing the C-terminal alpha-amidation of peptidylglycine substrates, yielding amidated products
  • being in charge of the formation of the C-terminal amides of biologically active peptides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by SSB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS