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FLASH GENE

Symbol

PALM

contributors: mct - updated : 16-05-2011

HGNC name	paralemmin
HGNC id	8594

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 708.952 - 748.330
Synonym symbol(s)	KIAA0270

DNA

TYPE	functioning gene
STRUCTURE	39.38 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001040134 8 - 2758 - 343 - 2005 16323283 Palmdelphin lacking an alternate in-frame exon lipid raft-associated protein implicated in cell shape control may peripherally associate with endomembranes or cytoskeleton-linked structures NM_002579 9 - 2890 42 387 - 2005 16323283

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland medulla     moderately Nervous brain       highly Homo sapiens Reproductive male system testis     highly Urinary kidney         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous autonomous       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

to the inner side of plasma membrane through a C terminal, prenylpalmitoyl anchor

conjugated

LipoP , PhosphoP

HOMOLOGY

interspecies

ortholog to murine Palm

Homologene

FAMILY

paralemmin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	localizes to dendritic membranes

basic FUNCTION	may be involved in control of cell shape
	implicated as a potent modulator of cellular cAMP signaling within the brain (
	role in the formation and stabilization of plasma
	membrane elaborations, in neurons as well as in other cell types
	regulator of filopodia induction and spine maturation
	key role in spine maturation through modulation of filopodia induction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

neurotransmission

a component

constituent of brain synaptic plasma membranes (inner side)

INTERACTION

DNA

RNA

small molecule

protein	specifically interacts with the third intracellular loop of the D3 dopamine receptor
	interacting with ZDHHC8, ZDHHC3 that modulates paralemmin-1 palmitoylation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS