basic FUNCTION
| p21/Cdc42/Rac1-activated kinase 3, serine/threonine kinase |
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involved in signal transduction for cell shape and motility as well as actin organization |
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acting as a key regulator of synapse formation and plasticity in the hippocampus |
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role for negative regulators of lamellipodial formation, like PAK3, in the maintenance of a poised state, in which regulated directional cell movement can occur |
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cooperate with PAK2, PAK1 kinase, and CHL1, most likely in independent pathways, in regulating morphological development of the leading process/apical dendrite of embryonic cortical neurons |
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having functions in novel signaling pathways in NF2 |
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essential role of PAK1 and PAK3 in coordinating neuronal complexity and synaptic properties |
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critical molecule coordinating cytoskeletal systems for efficient cell migration |
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novel function of PAK3 in regulating activity-mediated rearrangement of synaptic connectivity associated with learning and suggest that defects in spine formation and refinement during development could account for intellectual disability |
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PAK1 and PAK3 belong to group I of the PAK family and control cell movement and division |
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PAK3 and PAK1 signaling may be coordinated by heterodimerization |
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MTURN and PAK3, are both required for, and can synergize to promote differentiation of the primary neurons |
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is a novel regulator of pancreatic beta-cell differentiation and function |
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in the adult, PAK3 is required for the proper control of glucose homeostasis under challenging high-fat diet (HFD) |
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functions downstream of guidance receptor signaling to regulate the level and distribution of F-actin in migrating border cells |
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EPHB2, CDC42, and PAK3 are broadly capable of controlling dendritic spine formation and synaptic plasticity and are implicated in multiple cognitive disorders |
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key regulator of actin dynamics, cell proliferation and cell survival |
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developmental and cell-autonomous role for PAK3 in regulating oligodendrocyte precursors (OPCs) differentiation into mature oligodendrocytes |