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FLASH GENE
Symbol PAK2 contributors: mct/npt/pgu - updated : 16-03-2018
HGNC name p21 protein (Cdc42/Rac)-activated kinase 2
HGNC id 8591
Location 3q29      Physical location : 196.466.727 - 196.559.516
Synonym name
  • S6/H4 kinase
  • p21 (CDKN1A)-activated kinase 2
  • p21-activated kinase 2
  • Synonym symbol(s) PAK65, PAKgamma, p58
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 92.80 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 7500 - - predominant in all tissues except muscle where the level is equal than 3 kb level 1995 7744004
    15 splicing 6139 - 524 in most tissues 1995 7744004
    - splicing 4400 - - in most tissues 1995 7744004
    - splicing 3000 - - - 1995 7744004
    equal level than 7.5 kb level in muscle
    - splicing 3300 - - in brain 1995 7744004
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GBD domain
  • a C-terminal regulatory domain with RAC1/CDC42-binding domains (CRIB)
  • a C-terminal kinase region
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pak1,Pak3,Pak2
    homolog to rattus Rn10116,Pak1,Pak3
    homolog to Drosophila Cg10295,Pak
    homolog to C.elegans Pak1,Y38f1a.10,C09b8.7
    intraspecies homolog to PAK1
    homolog to PAK3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • protein kinase inhibition
  • linking Rho GTPases to cytoskeleton reorganization and nuclear signaling
  • playing a role in the regulation of the biochemistry and morphology of the apoptotic cell
  • phosphorylating ribosomal protein S6, histone H4 and myelin basic protein
  • regulates spindle orientation in a CDC42/Rac1 binding-dependent and kinase activity-independent manner
  • cooperate with PAK1, PAK3 kinase, and CHL1, most likely in independent pathways, in regulating morphological development of the leading process/apical dendrite of embryonic cortical neurons
  • critical molecule coordinating cytoskeletal systems for efficient cell migration
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GTP bound CDC42/p21 and RAC1
  • binding to Scrib-ARHGEF7-GIT1 complex
  • MAPK6 is a potential PAK2 substrate
  • cell & other
    REGULATION
    activated by proteolytic cleavage during caspase-mediated apoptosis by DEVD-sensitive caspase(s)
    Rho family GTPase (CDC42 and RAC1) by induction of autophosphorylation
    FMLP stimulation of neutrophils
    by Rac or Cdc42 stimulates cell survival and protects cells from cell death
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    enhances RhoA activity and inhibition of RhoA signaling in PAK22-depleted cells decreases myosin light chain phosphorylation and restores cell invasion in breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS