Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PAK2 contributors: mct/npt/pgu - updated : 03-09-2009
HGNC name p21 protein (Cdc42/Rac)-activated kinase 2
HGNC id 8591
Location 3q29      Physical location : 196.466.727 - 196.559.516
Synonym name
  • S6/H4 kinase
  • p21 (CDKN1A)-activated kinase 2
  • p21-activated kinase 2
  • Synonym symbol(s) PAK65, PAKgamma, p58
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 92.80 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CENTB2 3q29 centaurin, beta 2 PPP1R2 3q29 protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC391606 3 similar to ribosomal protein L24 LOC255812 3q29 hypothetical protein LOC255812 LOC389187 3 LOC389187 MUC20 3q29 mucin 20 MUC4 3q29 mucin 4, tracheobronchial LOC285253 3q29 similar to SPBPJ4664.02 ACK1 3q29 activated Cdc42-associated kinase 1 LOC391607 3 hypothetical gene supported by AJ271448; NM_174907 LOC375386 3q29 similar to Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (Fp) (Flavoprotein subunit of complex II) LOC391608 3 hypothetical gene supported by AJ271448; NM_174907 TFRC 3q29 transferrin receptor (p90, CD71) ZDHHC19 3q29 zinc finger, DHHC domain containing 19 OSTalpha 3q29 organic solute transporter alpha PCYT1A 3q21-q28 phosphate cytidylyltransferase 1, choline, alpha isoform MGC33212 3q29 hypothetical protein MGC33212 LOC116211 3q29 hypothetical protein BC013113 KIAA0794 3q29 hypothetical protein BC013113 LOC389188 3 LOC389188 FLJ35794 3q29 hypothetical protein FLJ35794 LOC255798 3q29 hypothetical protein LOC255798 MGC64882 3q29 hypothetical protein MGC64882 LOC200933 3q29 hypothetical protein LOC200933 LOC389189 3 LOC389189 UNQ3030 3q29 ELLP3030 MGC14126 3q29 hypothetical protein MGC14126 FLJ20522 3q29 hypothetical protein FLJ20522 PAK2 3q29 p21 (CDKN1A)-activated kinase 2 MGC27076 3q29 hypothetical protein MGC27076 NCBP2 3q29 nuclear cap binding protein subunit 2, 20kDa LOC152217 3q29 hypothetical protein BC007882 SMP3 3q29 SMP3 mannosyltransferase LOC389190 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) MFI2 3q28-q29 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 LOC391609 3 similar to immediate early protein homolog DLG1 3q29 discs, large (Drosophila) homolog 1 LOC391610 3 LOC391610 BDH 3q29 3-hydroxybutyrate dehydrogenase (heart, mitochondrial) LOC220729 3q29 similar to succinate dehydrogenase flavoprotein subunit LOC389191 3 hypothetical gene supported by BC053580 KIAA0226 3q29 KIAA0226 gene product DKFZp761B1514 3q29 hypothetical protein DKFZp761B1514 MGC4126 3q29 hypothetical protein MGC4126 DKFZp434B227 3q29 hypothetical protein DKFZp434B227 RPL35A 3q29-qter ribosomal protein L35a LMLN 3q29 leishmanolysin-like (metallopeptidase M8 family)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 7500 - - predominant in all tissues except muscle where the level is equal than 3 kb level 1995 7744004
    15 splicing 6139 - 524 in most tissues 1995 7744004
    - splicing 4400 - - in most tissues 1995 7744004
    - splicing 3000 - - - 1995 7744004
    equal level than 7.5 kb level in muscle
    - splicing 3300 - - in brain 1995 7744004
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GBD domain
  • a C-terminal regulatory domain with RAC1/CDC42-binding domains (CRIB)
  • a C-terminal kinase region
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pak1,Pak3,Pak2
    homolog to rattus Rn10116,Pak1,Pak3
    homolog to Drosophila Cg10295,Pak
    homolog to C.elegans Pak1,Y38f1a.10,C09b8.7
    intraspecies homolog to PAK1
    homolog to PAK3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • protein kinase inhibition
  • linking Rho GTPases to cytoskeleton reorganization and nuclear signaling
  • playing a role in the regulation of the biochemistry and morphology of the apoptotic cell
  • phosphorylating ribosomal protein S6, histone H4 and myelin basic protein
  • regulates spindle orientation in a CDC42/Rac1 binding-dependent and kinase activity-independent manner
  • cooperate with PAK1, PAK3 kinase, and CHL1, most likely in independent pathways, in regulating morphological development of the leading process/apical dendrite of embryonic cortical neurons
  • critical molecule coordinating cytoskeletal systems for efficient cell migration
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GTP bound CDC42/p21 and RAC1
  • binding to Scrib-ARHGEF7-GIT1 complex
  • MAPK4 is a potential PAK2 substrate
  • cell & other
    REGULATION
    activated by proteolytic cleavage during caspase-mediated apoptosis by DEVD-sensitive caspase(s)
    Rho family GTPase (CDC42 and RAC1) by induction of autophosphorylation
    FMLP stimulation of neutrophils
    by Rac or Cdc42 stimulates cell survival and protects cells from cell death
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    enhances RhoA activity and inhibition of RhoA signaling in PAK22-depleted cells decreases myosin light chain phosphorylation and restores cell invasion in breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS