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FLASH GENE
Symbol PAK1IP1 contributors: mct - updated : 16-11-2011
HGNC name PAK1 interacting protein 1
HGNC id 20882
Location 6p24.2      Physical location : 10.695.187 - 10.709.968
Synonym name PAK/PLC-interacting protein 1
Synonym symbol(s) FLJ20624, hPIP1, PIP1, bA421M1.5, MAK11, WDR84, RP11-421M1.5
DNA
TYPE functioning gene
STRUCTURE 14.78 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1511 - 392 - 2001 11371639
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five WD40 repeats
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • inhibits PAK signaling by stabilizing PAK1 in the inactive conformation
  • can block PAK-mediated JNK and NFK-B signaling pathways
  • a potential role in actin cytoskeletal organization
  • its overexpression inhibited cell proliferation by inducing TP53-dependent G1 cell-cycle arrest
  • new nucleolar protein that is crucial for rRNA processing and plays a regulatory role in cell proliferation via the TP53-MDM2 loop
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PAK1 binding
  • bound to MDM2 and inhibited its ability to ubiquitinate and to degrade TP53, consequently leading to the accumulation of TP53 levels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS