Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PAICS contributors: - updated : 27-04-2007
HGNC name phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
HGNC id 8587
Location 4q12      Physical location : 57.301.914 - 57.327.534
Synonym symbol(s) AICAR, AIR, AIRC, CAIR, ADE2, PAIS, ADE2H1
EC.number 4.1.1.21, 6.3.2.6
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
KDR 4q12 kinase insert domain receptor (a type III receptor tyrosine kinase) FLJ13352 4q12 hypothetical protein FLJ13352 TPARL 4q12 TPA regulated locus CLOCK 4q12 clock homolog (mouse) GCPHLP 4q12 likely ortholog of mouse germ cell-specific phosphoducin-like protein Mgcphlp NMU 4q12 neuromedin U SEC3 FLJ13621 4q12 hypothetical protein FLJ13621 KIAA0635 4q12-q13.3 hypothetical protein FLJ13621 KIAA1211 4q12 KIAA1211 protein MRPL22P1 4q12 KIAA1211 protein NRPS998 4q12 2-aminoadipic 6-semialdehyde dehydrogenase PPAT 4q12 phosphoribosyl pyrophosphate amidotransferase PAICS 4q12 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase SRP72 1q32 signal recognition particle 72kDa LOC132946 4q12 similar to MGC69138 protein LOC391654 4 LOC391654 GLDCP 4q12 glycine dehydrogenase (decarboxylase) pseudogene HOP 4q11-q12 homeodomain-only protein LOC391655 4 similar to 60S ribosomal protein L17 (L23) LOC285453 4q12 similar to APACD protein SPINK2 4q12 serine protease inhibitor, Kazal type, 2 (acrosin-trypsin inhibitor) REST 4q12 RE1-silencing transcription factor MGC3232 POLR2B 4q12 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa IGFBP7 4q12 insulin-like growth factor binding protein 7 LOC255130 4q12 hypothetical LOC255130
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3350 47 432 - -
- splicing 3350 46 425 - -
  • differing in the 5' UTR
  • lacking an alternate in-frame exon in the CDS compared to variant 1
  • encoding the same isoform than variant 3
  • - splicing 3329 46 425 - -
  • lacking an alternate in-frame exon in the CDS compared to variant 1
  • encoding the same isoform than variant 2
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     liver   moderately
     stomach   highly
    Endocrineneuroendocrinepituitary  predominantly
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemuteruscervix moderately
     male systemtestis  moderately
    Skin/Tegumentskin   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood, highly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to chimpanzee PAICS (98.6 pc)
    homolog to rattus Paics (96.2 pc)
    homolog to murine Paics (95.1 pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as a succinyl-aminoimidazole carboxamide ribonucleotide (SAICAR) synthetase
  • acting as an aminoimidazole ribonucleotide (AIR) carboxylase (complementing Ade-D mutants in CHO cells)
  • catalyzing respectively the sixth and seventh steps of the novo purine biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
  • purine biosynthesis
  • a component
  • phosphoribosylaminoimidazole carboxylase complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    complementing Ade-D mutants in CHO cells