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FLASH GENE
Symbol PADI2 contributors: mct - updated : 18-01-2017
HGNC name peptidyl arginine deiminase, type II
HGNC id 18341
Location 1p35.2-p35.1      Physical location : 17.393.256 - 17.445.948
Synonym symbol(s) KIAA0994, PDI2
EC.number 3.5.3.15
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 50.00 kb     16 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 salivary glandsubmaxillary   
Nervousbrain    
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis   Homo sapiens
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
poly N-glycosylation sites
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine protein-arginine deiminase
intraspecies homolog to peptidylarginine deiminases
Homologene
FAMILY PAD family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • catalyzing the post-translational modification of proteins through the conversion of arginine to citruline in the presence of Ca2+ ions
  • playing an important role during terminal differentiation of epidermal keratinocytes
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • filaggrin, trichoyalin
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
    • cell & other
    REGULATION
    induced by sex steroid hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS