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FLASH GENE
Symbol PACSIN2 contributors: mct/npt/pgu - updated : 26-09-2017
HGNC name protein kinase C and casein kinase substrate in neurons 2
HGNC id 8571
Location 22q13.2      Physical location : 43.265.771 - 43.411.184
Synonym name
  • syndapin II
  • protein kinase C and casein kinase substrate in neurons 2
  • pacsin 2
  • Synonym symbol(s) PAC2, SDPII
    DNA
    TYPE functioning gene
    STRUCTURE 76.11 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    SEPT3 22q13.2 septin 3 MGC26816 22q13.31 hypothetical protein MGC26816 NAGA 22q13.2 N-acetylgalactosaminidase, alpha- LOC150368 22q13.31 hypothetical protein LOC150368 LOC91689 22q13.31 hypothetical gene supported by AL449243 NDUFA6 22q13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa LOC246785 22q13.2 PTD004 pseudogene CYP2D8P2 22q11.22-q11.23 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 CYP2D8P1 22q13.2-q13.31 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 1 TCF20 22q13.3 transcription factor 20 (AR1) LOC388906 22 hypothetical gene supported by BC039496 LOC150371 22q13.31 hypothetical LOC150371 NFAM1 22q13.31 NFAT activation molecule 1 SERHL 22q13.2-q13.31 serine hydrolase-like CGI-96 22q13.2-q13.31 CGI-96 protein dJ222E13.1 22q13 kraken-like dJ222E13.2 22q13.31 similar to CGI-96 PDIP46 RNU12P 22 RNA, U12 small nuclear pseudogene DIA1 22q13.2 diaphorase (NADH) (cytochrome b-5 reductase) A4GALT 22q13.2 alpha 1,4-galactosyltransferase LOC388907 22 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC391337 22 similar to hypothetical protein ARFGAP3 22q13.2-q13.3 ADP-ribosylation factor GTPase activating protein 3 PACSIN2 22q13.31 protein kinase C and casein kinase substrate in neurons 2 TTLL1 22q13.1 tubulin tyrosine ligase-like 1 BIK 22q13.31 BCL2-interacting killer (apoptosis-inducing) MT 22q13.31 malonyl-CoA:acyl carrier protein transacylase (malonyltransferase) BZRP 22q13.31 benzodiazapine receptor (peripheral) KIAA0153 22q13.31 benzodiazapine receptor (peripheral) SCUBE1 22q13.2-q13.3 signal peptide, CUB domain, EGF-like 1 DKFZp547I094 22q13.31 hypothetical protein DKFZp547I094 LOC388908 22 similar to chromosome 22 open reading frame 1; adult brain protein 239 FLJ23588 22q13.1-q13.33 CAP-binding protein complex interacting protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2171 - 486 - 2008 18456257
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouth   highly
    Nervousnervecranial nerve  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one FCH domain
  • hydrophobic loops and the basic AAs on the concave surface of the EFC/F-BAR domain are essential for both the microspike formation and tubulation , and F-BAR domain interacts directly with caveolin-1 by unmasking autoinhibition of PACSIN2
  • a SH3 domain at the C terminus, SH3 domain-mediated autoregulation of the membrane-deforming activity of F-BAR domains that is of crucial importance for its function
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pacsin2
    Homologene
    FAMILY
  • PACSIN family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text localized to the plasma membrane via its coiled-coil domain
    basic FUNCTION
  • cytoplasmic adaptor protein
  • cytoplasmic phosphoproteins that play a role in vesicle formation and transport
  • in addition to a crucial role in endocytic internalization, complexes with EHDs play an important role in endocytic receptor recycling
  • participate in cellular membrane trafficking, in regulation of dynamin-mediated endocytotic processes and have been shown to generate membrane tubules
  • may control other proteins during development
  • may regulate gastrulation by controlling the population of activated alpha5beta1 integrin and cytoskeleton strength during cell movement
  • function in dynamic microtubuli nucleation
  • intracellular adapter protein involved in vesicle transport, membrane dynamics and actin reorganisation
  • novel function for PACSIN1, PACSIN2, PACSIN3 in dynamic microtubuli nucleation
  • regulates cell spreading and migration, which are dependent on CCND1 expression
  • mediates membrane sculpting by caveolin-1 in caveola morphology and recruits dynamin-2 for caveola fission
  • F-BAR domain protein, able to associate with actin filaments using the same concave surface employed to bind to membranes, while some other tested N-BAR and F-BAR proteins (endophilin, CIP4 and FCHO2) do not associate with actin
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text organization of actin cytoskeleton
    PATHWAY
    metabolism
    signaling
    a component
  • compexing with EHD1, EHD2
  • components of the centrosome involved in microtubule dynamics
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin
  • negative regulator of ADAM13 proteolytic function
  • directly bound wild-type cyclin D1 (CCND1a) at the carboxyl terminus, and failed to bind CCND1b, the alternative splicing variant of cyclin D1
  • wedge loop of PACSIN3 is more rigid as PACSIN1, PACSIN2, which influences the lateral interactions between assembled dimers
  • new role for PACSIN2 in the control of CDH5-based endothelial adhesion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS