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FLASH GENE
Symbol PACRG contributors: KTN/npt - updated : 10/09/2008
HGNC name PARK2 co-regulated
HGNC id 19152
Corresponding disease
PARK2 Parkinson disease 2, juvenile
Location 6q26      Physical location : 163.148.163 - 163.736.523
Synonym name
  • molecular chaperone/chaperonin-binding protein
  • Parkin coregulated gene protein
  • Synonym symbol(s) PARK2CRG, FLJ32724, GLUP, HAK005771, RP3-495O10.2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text upstream and in opposite orientation with PARK2
    STRUCTURE 588.40 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • a bidirectional promoter for PACRG and PARK2
  • an AP-4 like site, a GC-rich region and a MYC-like site
  • MAPPING cloned Y linked N status confirmed
    Physical map
    SOD2 6q25.2 superoxide dismutase 2, mitochondrial WTAP 6q25-q27 Wilms tumor 1 associated protein ACAT2 6q25.3-q26 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) TCP1 6q25.1-q25.2 t-complex 1 MRPL18 6q25.3 mitochondrial ribosomal protein L18 PNLDC1 6q25.3 poly(A)-specific ribonuclease (PARN)-like domain containing 1 MAS1 6q25.3-q26 MAS1 oncogene IGF2R 6q26-q27 insulin-like growth factor 2 receptor SLC22A1 6q27 solute carrier family 22 (organic cation transporter), member 1 SLC22A2 6q26-q27 solute carrier family 22 (organic cation transporter), member 2 SLC22A3 6q26-q27 solute carrier family 22 (extraneuronal monoamine transporter), member 3 APOAL 6q26-q27 apolipoprotein A-like LPA 6q26-q27 lipoprotein, Lp(a) PLG 6q26 plasminogen LOC389446 6 similar to apolipoprotein(a) (EC 3.4.21.-) - rhesus macaque (fragment) LOC389447 6 LOC389447 MAP3K4 6q25.3 mitogen-activated protein kinase kinase kinase 4 AGPAT4 6q25.3 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) C6orf59 6q25.3 chromosome 6 open reading frame 59 PARK2 6q25.2-q27 Parkinson disease (autosomal recessive, juvenile) 2, parkin PACRG 6q26 PARK2 co-regulated QKI 6q26-27 quaking homolog, KH domain RNA binding (mouse) LOC391985 6 similar to [Ascaris lumbricoides mRNA sequence.], gene product C6orf118 6q27 chromosome 6 open reading frame 118 PDE10A 6q26 phosphodiesterase 10A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1702 33.2 296 - -
    6 splicing 1585 29.2 257 - -
  • lacking an alternate in-frame exon compared to variant 1,
  • encoding the same isoform than variant 3
  • 5 splicing 1627 29.2 257 - -
  • lacking an exon at its 5' end and an in-frame internal exon compared to variant 1
  • encoding the same isoform than variant 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivestomach    
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Reproductivemale systemtestis  highly
    Respiratorylung   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatum   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunemacrophage
    NervousSchwann cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Pacrg (91.7 pc)
    homolog to chimpanzee PACRG (99.7 pc)
    homolog to dog PACRG (97.3 pc)
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text coexpressed with PARK2
    basic FUNCTION
  • suppressing cell-death induced by accumulation of unfolded GPR37 (PAELR)
  • facilitating the formation of GPR37 inclusions
  • may play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson's disease
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with HSP70, HSP90, chaperonin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with STIP1, PARK2, GPR37, HSPA8, CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8
  • binding to microtubules and alpha/beta-tubulin heterodimers with high affinity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PARK2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    Parkinson disease (component of Lewy bodies )
    Susceptibility to leprosy
    Variant & Polymorphism SNP increasing the susceptibility to leprosy
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS