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FLASH GENE
Symbol PABPC3 contributors: SGE/npt - updated : 11-06-2010
HGNC name poly(A) binding protein, cytoplasmic 3
HGNC id 8556
Location 13q12.13      Physical location : 25.670.275 - 25.672.702
Synonym name
  • testis-specific poly(A)-binding protein 3
  • polyadenylate-binding protein 3
  • poly(A)-binding protein-like 3
  • Synonym symbol(s) PABPL3, PABP3, tPABP
    DNA
    TYPE functioning gene
    STRUCTURE 2.43 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • intronless
  • several AP2 and AP4 sites and others
  • CpG-rich promoter (Feral 2001)
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC387908 13 similar to Ferritin heavy chain (Ferritin H subunit) LOC390383 13 similar to inositol polyphosphate multikinase LOC387909 13 hypothetical gene supported by AK130366 LOC283530 13q12.12 hypothetical LOC283530 LOC387910 13 LOC387910 SGCG 13q12 sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) SACS 13q12 spastic ataxia of Charlevoix-Saguenay (sacsin) TNFRSF19 13q12.11-q12.3 tumor necrosis factor receptor superfamily, member 19 MIPEP 13q12 mitochondrial intermediate peptidase LOC387911 13 similar to hypothetical protein MGC48915 LOC390384 13 similar to hypothetical protein DKFZp434A171 SPATA13 13q12.13 spermatogenesis associated 13 MGC48915 13q12.13 hypothetical protein MGC48915 LOC390385 13 similar to hypothetical protein, MGC:7199 HCP33 13q12.13 cytochrome c, somatic pseudogene ADPRTL1 13q11 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 LOC387912 13 similar to TPTE and PTEN homologous inositol lipid phosphatase ATP12A 13q12.1-q12.3 ATPase, H+/K+ transporting, nongastric, alpha polypeptide LOC390386 13 similar to hypothetical protein DKFZp434A171 RNF17 13q12 ring finger protein 17 TDRD4 13q12.12 tudor domain containing 4 CENPJ 13q12.13 centromere protein J LOC387913 13 similar to TPTE and PTEN homologous inositol lipid phosphatase LOC390387 13 similar to Striatin PABPC3 13q11-q12 poly(A) binding protein, cytoplasmic 3 FLJ25477 13q12.13 hypothetical protein FLJ25477 MTMR6 13q12 myotubularin related protein 6 NUPL1 13q12.12 nucleoporin like 1 LOC246717 13q12 transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene ATP8A2 13q12-13 ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2 LOC387914 13 similar to WGAR9166 RNF6 13q12 ring finger protein (C3H2C3 type) 6 CDK8 13q12 cyclin-dependent kinase 8 WASF3 13q12 WAS protein family, member 3 LOC390389 13 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 GPR12 13q12 G protein-coupled receptor 12 USP12 5q33-q34 ubiquitin specific protease 12 RPL21 13pter-p13 ribosomal protein L21 LOC254109 13q12.2 similar to MGC53580 protein GTF3A 13q12.3-q13.1 general transcription factor IIIA MTIF3 13q12.2 mitochondrial translational initiation factor 3 PDZRN1 13q12.2 PDZ domain containing ring finger 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2430 - 631 - Feral (2001)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four RRM domains
  • one PABC domain
  • conjugated PhosphoP
    HOMOLOGY
    intraspecies paralog to PABPC1
    Homologene
    FAMILY
  • poly(A)-binding protein type-1 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in cytoplasmic regulatory processes of mRNA metabolism
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • maybe complexing with the eukaryotic initiation complex eIF4F
  • INTERACTION
    DNA
    RNA
  • binding the poly(A) tail of mRNA
  • could bind RNA homopolymers (Feral 2001)
  • small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS