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FLASH GENE
Symbol PABPC3 contributors: SGE/npt - updated : 11-06-2010
HGNC name poly(A) binding protein, cytoplasmic 3
HGNC id 8556
Location 13q12.13      Physical location : 25.670.275 - 25.672.702
Synonym name
  • testis-specific poly(A)-binding protein 3
  • polyadenylate-binding protein 3
  • poly(A)-binding protein-like 3
  • Synonym symbol(s) PABPL3, PABP3, tPABP
    DNA
    TYPE functioning gene
    STRUCTURE 2.43 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • intronless
  • several AP2 and AP4 sites and others
  • CpG-rich promoter (Feral 2001)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2430 - 631 - Feral (2001)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four RRM domains
  • one PABC domain
  • conjugated PhosphoP
    HOMOLOGY
    intraspecies paralog to PABPC1
    Homologene
    FAMILY
  • poly(A)-binding protein type-1 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in cytoplasmic regulatory processes of mRNA metabolism
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • maybe complexing with the eukaryotic initiation complex eIF4F
  • INTERACTION
    DNA
    RNA
  • binding the poly(A) tail of mRNA
  • could bind RNA homopolymers (Feral 2001)
  • small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS